Publication:
Comparison of the effects of rutaecarpine on molecular subtypes of breast cancer

dc.contributor.authorÇokluk, Erdem
dc.contributor.authorÖzman, Zeynep
dc.contributor.authorGüney, Gamze
dc.contributor.authorDeveci, Asuman
dc.contributor.authorŞekeroğlu, Mehmet Ramazan
dc.contributor.institutionauthorÖZMAN, ZEYNEP
dc.date.accessioned2021-09-15T20:59:11Z
dc.date.available2021-09-15T20:59:11Z
dc.date.issued2021-06-01T00:00:00Z
dc.description.abstractObjective: Natural compounds have gained considerable attention in recent years due to disadvantages and properties of current chemotherapy drugs in cancer therapy. In addition, the impact of these compounds is specific for each type and/or subtypes of cancer due to different treatment response. Rutaecarpine, an alkaloid obtained from Evodia Rutaecarpa Chinese herb, has anticancer activity by inhibiting topoisomerase and/or cyclo-oxygenase-2 levels. However, the effectiveness of rutaecarpine has not been well known in breast cancer in terms of subtype. Therefore, we investigated the potential therapeutic effects of rutaecarpine on two different subtypes of breast cancer cells. Materials and methods: The cytotoxic and apoptotic effects of rutaecarpine on MCF-7 and MDA-MB-231 cells were analyzed by WST-1, Annexin V, cell cycle, and acridine orange staining. Results: WST-1 results indicated that rutaecarpine significantly inhibited the growth of both cancer cells for 48 h (P < 0.05). In addition, rutaecarpine treatment caused apoptotic cell death through chromatin condensation and nuclear blebbing and G0/G1 arrest in both breast cancer cells. However, the efficacy of rutaecarpine was more profound in MCF-7 cells than MDA-MB-231 cells. Conclusions: Consequently, rutaecarpine has a potential therapeutic effect on breast cancer. However, the effectiveness of rutaecarpine is dependent on the subtype of breast cancer.
dc.identifier.doi10.4103/jcrt.jcrt_1182_20
dc.identifier.pubmed34528553
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29455
dc.subjectApoptosis
dc.subjectbreast cancer
dc.subjectrutaecarpine
dc.subjectsubtype
dc.titleComparison of the effects of rutaecarpine on molecular subtypes of breast cancer
dc.typeArticle
dspace.entity.typePublication
local.avesis.ida8df6649-9499-4995-9f06-e238d092fed8
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication14ea756c-5a6f-4c3b-86f7-4344ad265721
relation.isAuthorOfPublication.latestForDiscovery14ea756c-5a6f-4c3b-86f7-4344ad265721
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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