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Radiological and Stereological Evaluation of the Effect of Rifampin on Bone Healing in Critical-Size Defects

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dc.contributor.authorDurmuslar, Mustafa Cenk
dc.contributor.authorBalli, UMUT
dc.contributor.authorTurer, Akif
dc.contributor.authorOnger, Mehmet E.
dc.contributor.authorÇELİK, HAKAN HAMDİ
dc.contributor.institutionauthorBALLI, UMUT
dc.date.accessioned2021-02-01T20:59:56Z
dc.date.available2021-02-01T20:59:56Z
dc.date.issued2016-09-01T00:00:00Z
dc.description.abstractObjectives:This study aimed to investigate the effect of rifampin with autogenous bone on bone regeneration in critical-size defects in the calvaria of rats.Materials and Methods:In total, 40 rats were divided into 4 groups and a 5-mm diameter of calvarial defect was made in each rat-s calvarium. Control group (C), bone defects were irrigated with sterile saline; rifampin group (R), bone defects were irrigated with rifampin. In the autogenous graft group (Ag), the autogenous graft was contaminated with saliva, and the defects were filled with an autogenous graft. In the autogenous graft + rifampin group (Ag+R), the autogenous graft was contaminated with saliva and was decontaminated with rifampin, and the defects were filled with the autogenous graft. The animals were killed at 4weeks. Bone formation was assessed by micro-computed tomography scanning and stereological analyses.Results:The mean new bone volume was the greatest in the Ag/rifampin group (1.730.17), followed by the Ag group (1.50 +/- 0.05) (statistically significant difference at P0.05).Conclusion:This study, despite its limitations, showed that rifampin with autogenous bone increased bone regeneration in rats with critical-size defects.
dc.identifier.citationDurmuslar M. C. , Balli U., Turer A., Onger M. E. , ÇELİK H. H. , -Radiological and Stereological Evaluation of the Effect of Rifampin on Bone Healing in Critical-Size Defects-, JOURNAL OF CRANIOFACIAL SURGERY, cilt.27, ss.1481-1485, 2016
dc.identifier.doi10.1097/scs.0000000000002762
dc.identifier.scopus84988378125
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28267
dc.identifier.wosWOS:000384271100056
dc.titleRadiological and Stereological Evaluation of the Effect of Rifampin on Bone Healing in Critical-Size Defects
dc.typeArticle
dspace.entity.typePublication
local.avesis.idda70662f-52ac-43cf-9e79-1393ee90a4c7
local.publication.isinternational1
relation.isAuthorOfPublication98da5869-ea4b-40c5-873f-9bbd29c50a23
relation.isAuthorOfPublication.latestForDiscovery98da5869-ea4b-40c5-873f-9bbd29c50a23
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