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Assessing the influence of cycloastragenol on telomere/telomerase system of Arabidopsis thaliana

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dc.contributor.authorCeylan, Merve
dc.contributor.authorKINA, ÜMİT YAŞAR
dc.contributor.authorCakir, Ozgur
dc.contributor.authorKara, Neslihan Turgut
dc.contributor.institutionauthorKINA, ÜMİT YAŞAR
dc.date.accessioned2021-03-30T20:59:10Z
dc.date.available2021-03-30T20:59:10Z
dc.date.issued2021-03-01T00:00:00Z
dc.description.abstractCycloastragenol (CAG) is a triterpenoid saponin compound that is synthesized by Astragalus species. CAG has many bioactivity, including telomerase activation, telomere elongation, anti-inflammatory, and anti-oxidative properties. While CAG activates human telomerase, no study has been conducted to investigate its effect on the plant telomere/telomerase system. In this study, in order to test whether CAG has an impact on plants, 1 mu M and 10 mu M CAG were tested on all in vitro grown plant and callus tissues of a model plant Arabidopsis thaliana. Results revealed that CAG caused an increase in the transcript levels of TER1, CTC1, TRB1, POT1a, TAC1, BT2 which act as positive regulators on the telomere/telomerase system together with the TERT gene encoding the catalytic subunit of telomerase especially calli tissues in A.thaliana. While CAG administration resulted in increase in height, and no remarkable effect on callus growth index was observed. Furthermore, no significant change in cell proliferation was observed in plant root cells due to the CAG treatment. The gene expression results suggest that CAG induced transcription of positive regulators of telomere/telomerase system and it might have a role in plants as well as in humans.
dc.identifier.citationCeylan M., KINA Ü. Y. , Cakir O., Kara N. T. , -Assessing the influence of cycloastragenol on telomere/telomerase system of Arabidopsis thaliana-, PLANT CELL TISSUE AND ORGAN CULTURE, 2021
dc.identifier.doi10.1007/s11240-021-02047-w
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28644
dc.identifier.wosWOS:000631765800001
dc.titleAssessing the influence of cycloastragenol on telomere/telomerase system of Arabidopsis thaliana
dc.typeArticle
dspace.entity.typePublication
local.avesis.ida57f112a-823b-41ad-af3c-d433ec44985f
local.publication.isinternational1
relation.isAuthorOfPublicationc3765050-04eb-4a05-9f88-b9913d0f1f06
relation.isAuthorOfPublication.latestForDiscoveryc3765050-04eb-4a05-9f88-b9913d0f1f06
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