Publication:
Effects of fetal alcohol and maternal intubation stress on the expression of proteins controlling postnatal development of male rat hippocampus

Simple item page
dc.contributor.authorELİBOL, BİRSEN
dc.contributor.authorBEKER, MERVE
dc.contributor.authorKILIÇ, ÜLKAN
dc.contributor.authorJakubowska-Dogru, Ewa
dc.contributor.institutionauthorELİBOL, BİRSEN
dc.contributor.institutionauthorBEKER, MERVE
dc.date.accessioned2020-10-22T21:35:40Z
dc.date.available2020-10-22T21:35:40Z
dc.date.issued2020-09-01T00:00:00Z
dc.description.abstractBackground Developing brains can partially get over prenatal alcohol exposure-related detrimental conditions by activating some mechanisms involved in survival. Objectives This study aimed to shed light on the molecular correlates of compensatory mechanisms by examining temporal profiles in the expression of proteins controlling postnatal development in the rat hippocampus prenatally exposed to intubation stress/ethanol. Methods Male pups were randomly assigned to age subgroups (n = 21/age) which were sacrificed on postnatal day (PD)1, PD10, PD30, and PD60. Ethanol (6 g/kg/day) were intragastrically intubated to the dams throughout 7-21 gestation days. The expression of neurogenesis and angiogenesis markers, extracellular matrix proteins, and growth-promoting ligands were examined by western blot. Results The most rapid increase in the index of neuronal maturation was noted between PD10-PD30 (p< .05). Prenatal stress caused a decrease of neurogenesis markers at birth and an increase of their expressions at PD10 and PD30 to reach control levels (p< .001). The impact of fetal-alcohol was observed as a decrease in the expression of synaptic plasticity protein versican at birth (p< .001), an increase in the synaptic repulsion protein ephrin-B2 at PD10 (p< .001), and a decrease in the maturation of BDNF at PD30 (p< .001) with a decrease in the mature neuron markers at PD30 (p< .001) and PD60 (p= .005) which were compensated with upregulation of angiogenesis and increasing brevican expression, a neuronal maturation protein (p< .001). Conclusion These data providein vivoevidence for the potential therapeutic factors related to neurogenesis, angiogenesis, and neurite remodeling which may tolerate the alcohol/stress dependent teratogenicity in the developing hippocampus.
dc.description.sponsorshipTürkiye Bilimsel Ve Teknolojik Araştırma Kurumu ( Tubitak )
dc.identifier.citationELİBOL B., BEKER M., Jakubowska-Dogru E., KILIÇ Ü., -Effects of fetal alcohol and maternal intubation stress on the expression of proteins controlling postnatal development of male rat hippocampus-, AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE, 2020
dc.identifier.doi10.1080/00952990.2020.1780601
dc.identifier.pubmed32915069
dc.identifier.scopus85090980906
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24850
dc.identifier.wosWOS:000568911000001
dc.titleEffects of fetal alcohol and maternal intubation stress on the expression of proteins controlling postnatal development of male rat hippocampus
dc.typeArticle
dspace.entity.typePublication
local.avesis.ideea821a3-4599-4746-83f2-5e88e2aaa3b7
local.publication.isinternational1
relation.isAuthorOfPublication1b1887fb-6b32-44b1-9d9f-416616dc6734
relation.isAuthorOfPublication6f8a3a29-68af-47b4-b206-bbc6051b00f5
relation.isAuthorOfPublication.latestForDiscovery6f8a3a29-68af-47b4-b206-bbc6051b00f5
Files
Collections
Yayınlar - Eserler