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LC-MS quantification of parthenolide and cholinesterase inhibitory potential of selected Tanacetum L. (Emend. Briq.) taxa

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dc.contributor.authorOrhan, Ilkay Erdogan
dc.contributor.authorTosun, Fatma
dc.contributor.authorGulpinar, Ali Rifat
dc.contributor.authorKartal, MURAT
dc.contributor.authorDuran, Ahmet
dc.contributor.authorMihoglugil, Feyyaz
dc.contributor.authorAkalgan, Demet
dc.contributor.institutionauthorKARTAL, MURAT
dc.date.accessioned2020-10-29T23:06:51Z
dc.date.available2020-10-29T23:06:51Z
dc.date.issued2015-03-01T00:00:00Z
dc.description.abstractThe acetonitrile extracts of various Tanacetum L. (Emend. Briq.) taxa from Turkey as well as parthenolide, a sesquiterpene lactone found in Tanacetum species as active substance were investigated for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), the key enzymes in pathogenesis of Alzheimer-s disease, at 100 mu g mL(-1) using ELISA microplate assay. Most of the extracts displayed a remarkable AChE inhibition where the leaf of Tanacetum argenteum subsp. flabellifolium had the highest inhibition (96.68 +/- 0.35%). The extracts had moderate inhibition toward BChE, among which the stem of Tanacetum argyrophyllum var. argyrophyllum-1 exerted the best inhibition (63.81 +/- 3.64%). However, parthenolide exhibited low inhibition against both of the enzymes. Total flavonoid content of the extracts was determined spectrophotometrically. Parthenolide, a sesquiterpene lactone, was quantified in these taxa by LC-MS and the leaf of T. argenteum subsp. argenteum possessed the richest parthenolide amount (2.261 +/- 0.002%), while most of the species screened were found to contain the required percentage (0.2% minimum) by European Pharmacopeia. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
dc.identifier.citationOrhan I. E. , Tosun F., Gulpinar A. R. , Kartal M., Duran A., Mihoglugil F., Akalgan D., -LC-MS quantification of parthenolide and cholinesterase inhibitory potential of selected Tanacetum L. (Emend. Briq.) taxa-, PHYTOCHEMISTRY LETTERS, cilt.11, ss.347-352, 2015
dc.identifier.doi10.1016/j.phytol.2014.10.003
dc.identifier.scopus84923552743
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26906
dc.identifier.wosWOS:000350569100064
dc.titleLC-MS quantification of parthenolide and cholinesterase inhibitory potential of selected Tanacetum L. (Emend. Briq.) taxa
dc.typeArticle
dspace.entity.typePublication
local.avesis.idd08c046f-1acb-4247-9bd8-429afad95764
local.publication.isinternational1
relation.isAuthorOfPublicationb30ec030-5f34-4c8b-814e-a7131d524a0a
relation.isAuthorOfPublication.latestForDiscoveryb30ec030-5f34-4c8b-814e-a7131d524a0a
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