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Effects of caffeic acid phenethyl ester on wound healing in calvarial defects

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dc.contributor.authorKazancioglu, Hakki Oguz
dc.contributor.authorAksakalli, Sertac
dc.contributor.authorAYDIN, MEHMET
dc.contributor.authorEzirganli, Seref
dc.contributor.authorBEREKET, MEHMET CİHAN
dc.date.accessioned2020-10-22T20:18:55Z
dc.date.available2020-10-22T20:18:55Z
dc.date.issued2015-01-01T00:00:00Z
dc.description.abstractObjective. The aim of this study is to analyze histologically the effect of CAPE on bone healing of Critical Size Defect (CSD) in rat calvaria. Study design. Thirty-two 3-month-old male rats were used. The animals were randomly divided into four groups. Group A received isotonic saline solution, Group B received CAPE (50 mmol/kg) locally, Group C received CAPE (100 mmol/kg) locally and Group D received CAPE (10 mmol/kg/day i.p. for 28 days) systematically. A 5-mm diameter calvarial defect was created in the right side of the parietal bone without damaging the underlying dura mater. Twenty-eight days after the surgery, all the animals were sacrificed. The original defect area was removed from the animal-s calvarium bone en bloc. Beginning at the center of the surgical defect, serial sections of 6 mm thick were cut longitudinally. The sections were stained with hematoxylin and eosin for analysis under a light microscope. The sections were analyzed for the presence of inflammatory infiltrate, connective tissue formation and new bone formation. Computer-assisted histomorphometic measurements were carried out with an automated image analysis system. Results. The total new bone areas were significantly greater in group D than in all groups and group C was statistically insignificant from the other groups (p 0.05), amount of total regenerated bone area than the control group. Conclusion. The results indicate that 100 mmol/kg topical and 10 mmol/kg/day systemic application of CAPE increases bone healing, especially with systemic application.
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier.citationKazancioglu H. O. , BEREKET M. C. , Ezirganli S., AYDIN M., Aksakalli S., -Effects of caffeic acid phenethyl ester on wound healing in calvarial defects-, ACTA ODONTOLOGICA SCANDINAVICA, cilt.73, ss.21-27, 2015
dc.identifier.doi10.3109/00016357.2014.942876
dc.identifier.pubmed25373514
dc.identifier.scopus84918514867
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24643
dc.identifier.wosWOS:000346333700004
dc.titleEffects of caffeic acid phenethyl ester on wound healing in calvarial defects
dc.typeArticle
dspace.entity.typePublication
local.avesis.idd5b45396-9ef2-46e4-9085-114a22c0d32f
local.publication.isinternational1
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