Publication:
The effect of systemic rifampicin treatment on inferior alveolar nerve regeneration in rats following crush injury

Simple item page
dc.contributor.authorDİKER, Nurettin
dc.contributor.authorCaglayan, Berrak
dc.contributor.authorHelvacioglu, Fatma
dc.contributor.authorKILIÇ, ERTUĞRUL
dc.contributor.institutionauthorDİKER, NURETTİN
dc.date.accessioned2020-06-05T20:59:50Z
dc.date.available2020-06-05T20:59:50Z
dc.date.issued2020-06-01T00:00:00Z
dc.description.abstractAxonal regeneration of the inferior alveolar nerve (IAN) is a therapeutic target for functional recovery after peripheral nerve injury. Rifampicin exerts anti-apoptotic, anti-inflammatory, and anti-oxidant effects on nerve tissues that may enhance functional recovery after peripheral nerve injury. The aim of the present study was to evaluate the therapeutic effects of systemic rifampicin following IAN crush injury. Following the nerve crush injuries of the IAN, 24 Sprague-Dawley rats were randomly divided into three groups to receive daily intraperitoneal injections of either vehicle, 5 mg kg(-1) rifampicin, or 20 mg kg(-1) rifampicin. Twenty-four days after induction of nerve injuries, Fluorogold (FG) was injected over the mental foramen for the evaluation of neuronal survival. At the end of the four-week period, histologic and histomorphometric examination of IAN samples were performed and FG positive cells were counted in the trigeminal ganglion sections. FG positive cells were significantly more frequent in the 20 and 5 mg kg(-1) rifampicin groups than in the vehicle-treated group. Electron microscopic analyses revealed that the percentage of axons with optimum g-ratio was significantly lower in the vehicle group than in both treatment groups. In conclusion, systemic rifampicin treatment can enhance peripheral nerve regeneration.
dc.identifier.citationDİKER N., Caglayan B., Helvacioglu F., KILIÇ E., -The effect of systemic rifampicin treatment on inferior alveolar nerve regeneration in rats following crush injury-, EUROPEAN JOURNAL OF ORAL SCIENCES, cilt.128, ss.183-189, 2020
dc.identifier.doi10.1111/eos.12691
dc.identifier.pubmed32236990
dc.identifier.scopus85082603379
dc.identifier.urihttps://hdl.handle.net/20.500.12645/18070
dc.identifier.wosWOS:000522524100001
dc.language.isoen
dc.titleThe effect of systemic rifampicin treatment on inferior alveolar nerve regeneration in rats following crush injury
dc.typeArticle
dspace.entity.typePublication
local.avesis.id6e435541-0111-4000-b252-36114c838195
local.publication.isinternational1
relation.isAuthorOfPublicationaad04544-dd5e-45d4-a15d-24365e416f6e
relation.isAuthorOfPublication.latestForDiscoveryaad04544-dd5e-45d4-a15d-24365e416f6e
Files
Collections
Yayınlar - Eserler