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A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey

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dc.contributor.authorDURDU, MURAT
dc.contributor.authorBozca, Burcin Cansu
dc.contributor.authorENLİ, SERVİNAZ
dc.contributor.authorYazici Ozgen, Zuleyha
dc.contributor.authorYAYLI, SAVAŞ
dc.contributor.authorAKTAN, ŞEBNEM
dc.contributor.authorMUTLU, DERYA
dc.contributor.authorERTURAN, İjlal
dc.contributor.authorAYVAZ ÇELİK, Havva Hilal
dc.contributor.authorMELİKOĞLU, Mehmet
dc.contributor.authorPALA, Erdal
dc.contributor.authorGursel Urun, Yildiz
dc.contributor.authorHARMAN, MEHMET
dc.contributor.authorBOZKURT ŞAVK, EKİN
dc.contributor.authorIsik, Selin
dc.contributor.authorDuygulu, Seniz
dc.contributor.authorImren, Isil Gogem
dc.contributor.authorFETTAHLIOĞLU KARAMAN, BİLGE
dc.contributor.authorKAYA ERDOĞAN, HİLAL
dc.contributor.authorKILIÇ, ARZU
dc.contributor.authorOzcelik, Sinan
dc.contributor.authorInan, Kiymet
dc.contributor.authorYilmaz, Mustafa Anil
dc.contributor.authorSanli, Hatice Erdi
dc.contributor.authorKalay Yildizhan, Incilay
dc.contributor.authorMÜLAYİM, MEHMET KAMİL
dc.contributor.authorCicek, Demet
dc.contributor.authorDemir, Betul
dc.contributor.authorYASAK GÜNER, RUKİYE
dc.contributor.authorBAYKAL SELÇUK, LEYLA
dc.contributor.authorGÜNDÜZ, KAMER
dc.contributor.authorDAYE, MUNİSE
dc.contributor.authorBORLU, MURAT
dc.contributor.authorÖKSÜM SOLAK, EDA
dc.contributor.authorDİZMAN, DİDEM
dc.contributor.authorGÜNEŞ, BEGÜM
dc.contributor.authorOzkur, Ezgi
dc.contributor.authorPolat, Mualla
dc.contributor.authorEskiocak, Ali Haydar
dc.contributor.authorUZUN, SONER
dc.contributor.institutionauthorDİZMAN, DİDEM
dc.contributor.institutionauthorGÜNEŞ, BEGÜM
dc.date.accessioned2021-10-26T20:59:15Z
dc.date.available2021-10-26T20:59:15Z
dc.date.issued2021-10-01T00:00:00Z
dc.description.abstractBackground The differentiation between the pemphigoid diseases is essential for treatment and prognosis. In Turkey, data on the incidence of these diseases are insufficient. Our aim in this study is to determine the incidence, demographics and clinical characteristics associated with diseases of the pemphigoid group. Methods We prospectively analysed 295 patients with pemphigoid who visited dermatology clinics of tertiary referral hospitals in 12 different regions of Turkey within a year. The diagnosis was based on clinical, histopathological, direct immunofluorescence (DIF) and serological (multivariant enzyme-linked immunosorbent assay [ELISA], indirect immunofluorescence and mosaic-based BIOCHIP) examinations. Clinical and demographic findings, aetiological factors and concomitant diseases observed in the patients were recorded. Results A total of 295 (female/male ratio: 1.7/1) patients with pemphigoid were diagnosed in 1-year period. The overall incidence rate of pemphigoid diseases was found to be 3.55 cases per million-years. The ratio of pemphigoid group diseases to pemphigus group diseases was 1.6. The most common pemphigoid type was bullous pemphigoid (BP, 93.2%). The others were epidermolysis bullosa acquisita (3.1%), pemphigoid gestationis (2.4%), linear IgA disease (1%) and mucous membrane pemphigoid (0.3%). The most common (26.8%) possible trigger of the bullous pemphigoid was gliptin derivative drugs. The most common concomitant diseases with pemphigoid were cardiovascular (27.8%) and neurological diseases (23.7%). Conclusions This study showed that the increased frequency of bullous pemphigoid reversed the pemphigoid/pemphigus ratio in Turkey. Further studies are warranted regarding the reasons for this increase.
dc.identifier.citationDURDU M., Bozca B. C. , ENLİ S., Yazici Ozgen Z., YAYLI S., AKTAN Ş., MUTLU D., ERTURAN İ., AYVAZ ÇELİK H. H. , MELİKOĞLU M., et al., -A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey-, AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2021
dc.identifier.doi10.1111/ajd.13731
dc.identifier.pubmed34642934
dc.identifier.scopus85116932716
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29593
dc.identifier.wosWOS:000706544700001
dc.titleA multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey
dc.typeArticle
dspace.entity.typePublication
local.avesis.id8b23871e-99e5-4697-86d0-4997ac43aaf9
local.publication.isinternational1
relation.isAuthorOfPublication5e2a3d26-3642-4711-8511-e475ab354ebb
relation.isAuthorOfPublication55b107bb-ad4d-4030-9b11-5fea3f0e0391
relation.isAuthorOfPublication.latestForDiscovery55b107bb-ad4d-4030-9b11-5fea3f0e0391
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