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Risk Factors Affecting Patterns of Antibiotic Resistance and Treatment Efficacy in Extreme Drug Resistance in Intensive Care Unit-Acquired Klebsiella Pneumoniae Infections: A 5-Year Analysis

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dc.contributor.authorKOC, Meliha Meric
dc.contributor.authorDurdu, BÜLENT
dc.contributor.authorHAKYEMEZ, Ismail N.
dc.contributor.authorAkkoyunlu, YASEMİN
dc.contributor.authorDaskaya, HAYRETTİN
dc.contributor.authorGultepe, BİLGE
dc.contributor.authorASLAN, Turan
dc.contributor.institutionauthorDURDU, BÜLENT
dc.contributor.institutionauthorMERİÇ KOÇ, MELİHA
dc.contributor.institutionauthorAKKOYUNLU, YASEMİN
dc.contributor.institutionauthorDAŞKAYA, HAYRETTİN
dc.contributor.institutionauthorSÜMBÜL, BİLGE
dc.date.accessioned2019-10-05T13:05:45Z
dc.date.available2019-10-05T13:05:45Z
dc.date.issued2019-01-07
dc.description.abstractBACKGROUND: We investigated the factors affecting antibiotic resistance in the intensive care unit (ICU)-related hospital-acquired infections caused by Klebsiella pneumoniae (KP-HAI) and the effects of antibiotics used for high-level antibiotic resistance on patient survival. MATERIAL AND METHODS: This retrospective study was performed at the adult ICU of Bezmialem Vakif University Hospital. Patients who were followed up between 01 January 2012 and 31 May 2017 were evaluated. Each KP strain was categorized according to resistance patterns and analyzed. The efficiency of antibiotic therapy for highly-resistant KP-HAI was determined by patients’ lifespans. RESULTS: We evaluated 208 patients. With the prior use of carbapenem, antibiotics against resistant Gram-positives, and tigecycline, it was observed that the resistance rate of the infectious agents had a significant increase. As the resistance category increases, a significant decrease was seen in the survival time. We observed that if the treatment combination included trimethoprim-sulfamethoxazole, the survival time became significantly longer, and tigecycline-carbapenem-colistin and tigecycline-carbapenem combination patients showed significantly shorter survival times. CONCLUSIONS: When the resistance increases, delays will occur in starting suitable and effective antibiotic treatment, with increased sepsis frequency and higher mortality rates. Trimethoprim-sulfamethoxazole can be an efficient alternative to extend survival time in trimethoprim-sulfamethoxazole-susceptible KP infections that have extensive drug resistance.en
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dc.identifier.citationDurdu B., KOC M. M. , HAKYEMEZ I. N. , Akkoyunlu Y., Daskaya H., Gultepe B., ASLAN T., -Risk Factors Affecting Patterns of Antibiotic Resistance and Treatment Efficacy in Extreme Drug Resistance in Intensive Care Unit-Acquired Klebsiella Pneumoniae Infections: A 5-Year Analysis-, MEDICAL SCIENCE MONITOR, cilt.25, ss.174-183, 2019
dc.identifier.doi10.12659/msm.911338
dc.identifier.pubmed30614487
dc.identifier.scopus85059500964
dc.identifier.urihttps://hdl.handle.net/20.500.12645/1294
dc.identifier.wosWOS:000455083300002
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleRisk Factors Affecting Patterns of Antibiotic Resistance and Treatment Efficacy in Extreme Drug Resistance in Intensive Care Unit-Acquired Klebsiella Pneumoniae Infections: A 5-Year Analysis
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTURKDERM-ARCHIVES OF THE TURKISH DERMATOLOGY AND VENEROLOGY
local.avesis.id1e4ca182-5b78-4303-8542-c85cd830a20f
local.avesis.response1164
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscoveryfc9e6e5e-089f-4a24-bc0e-7003bbed7005
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