Publication: Effects of atorvastatin on vascular intimal hyperplasia: an experimental rodent model.
| dc.contributor.author | Aydin, Unal | |
| dc.contributor.author | Ugurlucan, Murat | |
| dc.contributor.author | Gungor, Funda | |
| dc.contributor.author | Ziyade, Sedat | |
| dc.contributor.author | Inan, Bekir | |
| dc.contributor.author | Banach, Maciej | |
| dc.contributor.author | Kalko, Yusuf | |
| dc.contributor.author | Yasar, Tahsin | |
| dc.date.accessioned | 2023-05-16T17:10:01Z | |
| dc.date.available | 2023-05-16T17:10:01Z | |
| dc.description.abstract | Vascular intimal hyperplasia is associated with increased mortality and morbidity. The authors investigated the effects of atorvastatin on vascular intimal hyperplasia. | |
| dc.description.abstract | Rats were divided into 4 groups. Groups 1, 2, and 3 had experimental aortic injury and received intraperitoneal injection of atorvastatin, solvent, or 0.9% NaCl, respectively. Group 4 was a nonintervention (laparotomy only) control group. Animals were sacrificed after 3 weeks. Blood samples and injured aortic segment were analyzed. | |
| dc.description.abstract | Atorvastatin administration significantly lowered total and low-density lipoprotein cholesterol levels (P = .012 and P = .001, respectively), intima-media ratio (P = .002), and intimal smooth muscle cell accumulation (P < .05) in group 1. Luminal narrowing in animals in group 1 was significantly lower than that in animals in groups 2 and 3, but was higher than in animals in group 4 (P = .009). | |
| dc.description.abstract | Atorvastatin suppresses intimal hyerplasia and aids in intimal regeneration by lowering blood lipids and intimal smooth muscle cell accumulation. | |
| dc.identifier.pubmed | 18796450 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12645/38291 | |
| dc.language.iso | en | |
| dc.title | Effects of atorvastatin on vascular intimal hyperplasia: an experimental rodent model. | |
| dspace.entity.type | Publication | |
| local.indexed.at | PubMed |