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Serum Gamma-Glutamyl Transferase (GGT) Levels and Inflammatory Activity in Patients With Non-dipper Hypertension

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dc.contributor.authorAcikgoz, Nusret
dc.contributor.authorERMİŞ, NECİP
dc.contributor.authorYagmur, Julide
dc.contributor.authorCANSEL, MEHMET
dc.contributor.authorCuglan, Bilal
dc.contributor.authorPEKDEMİR, HASAN
dc.contributor.authorÖZDEMİR, Ramazan
dc.contributor.institutionauthorAÇIKGÖZ, NUSRET
dc.contributor.institutionauthorÖZDEMİR, RAMAZAN
dc.date.accessioned2021-02-01T21:00:05Z
dc.date.available2021-02-01T21:00:05Z
dc.date.issued2012-01-01T00:00:00Z
dc.description.abstractNon-dipper hypertension is associated with increased cardiovascular morbidity and mortality. We aimed to evaluate serum gamma-glutamyl transferase (GGT) level, which is accepted as a marker for oxidative stress and its relationship with inflammatory activity in patients with non-dipper hypertension. Age and sex matched 43 dipper hypertensive patients, 40 non-dipper patients, and 46 healthy subjects were included into the study. Serum GGT and C-reactive protein (CRP) levels were measured and compared between each of the groups. Serum GGT activity was higher in the non-dipper and the dipper hypertensive groups than in the control group (33.5 +/- 11.8 and 28.1 +/- 10.1 U/l, respectively, vs. 21.2 +/- 6.5U/l; p < 0.001). There was a statistically significant difference in serum GGT activity between the non-dippers and the dippers (p = 0.021). When compared with the control group, serum CRP levels were significantly increased in both the non-dipper and the dipper hypertensive groups (6.1 +/- 2.6 and 5.4 +/- 2.1 mg/l, respectively, vs. 2.8 +/- 1.7mg/L; p < 0.001). Increased CRP levels were higher in non-dippers than dippers (p = 0.046). A significant correlation was found between GGT and CRP measurements (r = 0.37, p = 0.002). Serum GGT levels, which are markers of the oxidative stress and CRP levels, are both increased in non-dipper hypertension. Increased GGT activity, found to be correlated with CRP levels, may be one of the reasons behind the non-dipper hypertension related cardiovascular complications.
dc.identifier.citationERMİŞ N., Yagmur J., Acikgoz N., CANSEL M., Cuglan B., PEKDEMİR H., ÖZDEMİR R., -Serum Gamma-Glutamyl Transferase (GGT) Levels and Inflammatory Activity in Patients With Non-dipper Hypertension-, CLINICAL AND EXPERIMENTAL HYPERTENSION, cilt.34, ss.311-315, 2012
dc.identifier.doi10.3109/10641963.2011.577485
dc.identifier.scopus84863902301
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28274
dc.identifier.wosWOS:000306476700002
dc.titleSerum Gamma-Glutamyl Transferase (GGT) Levels and Inflammatory Activity in Patients With Non-dipper Hypertension
dc.typeArticle
dspace.entity.typePublication
local.avesis.idfd61056e-5ea8-4e04-b7fa-537bb473629e
local.publication.isinternational1
relation.isAuthorOfPublication3c6f1693-fd8c-43c4-8f55-e1388d929a53
relation.isAuthorOfPublication6384fc88-e60f-4402-bacf-1f1b2120fb58
relation.isAuthorOfPublication.latestForDiscovery6384fc88-e60f-4402-bacf-1f1b2120fb58
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