Publication:
Timing of endoscopy in cirrhotic patients with acute variceal bleeding: protocol of a multicenter randomized controlled trial

dc.contributor.authorQi X.
dc.contributor.authorLi Y.
dc.contributor.authorLi B.
dc.contributor.authorLuo X.
dc.contributor.authorLiu X.
dc.contributor.authorZhang C.
dc.contributor.authorChen M.
dc.contributor.authorKong D.
dc.contributor.authorWu Y.
dc.contributor.authorRomeiro F. G.
dc.contributor.authoret al.
dc.date.accessioned2024-12-10T21:50:26Z
dc.date.available2024-12-10T21:50:26Z
dc.date.issued2024-01-01
dc.description.abstractBackground: Endoscopy is important for the diagnosis and treatment of acute upper gastrointestinal bleeding (AUGIB), especially acute variceal bleeding (AVB), in liver cirrhosis. However, the optimal timing of endoscopy remains controversial, primarily because the currently available evidence is of poor quality, and the definition of early endoscopy is also very heterogeneous among studies. Herein, a multicenter randomized controlled trial (RCT) is performed to explore the impact of the timing of endoscopy on the outcomes of cirrhotic patients with AVB.Methods: A total of 368 cirrhotic patients presenting with AUGIB who are highly suspected to be from AVB will be enrolled. They will be stratified according to the severity of liver function and clinical presentation at admission and then randomly assigned at a 1:1 ratio into early (within 12 h after admission) and delayed (within 12-24 h after admission) endoscopy groups within each stratum. The primary outcomes include the rates of 5-day failure to control bleeding after admission and 6-week rebleeding. The secondary outcomes include 6-week mortality and incidence of adverse events.Conclusion: Considering existing evidence originates from non-randomized studies, this RCT will provide high-quality evidence to uncover whether cirrhotic patients with AVB should undergo early endoscopy to control bleeding and improve survival.Trial registration: ClinicalTrials.gov identifier: NCT06031402.
dc.identifier.citationQi X., Li Y., Li B., Luo X., Liu X., Zhang C., Chen M., Kong D., Wu Y., Romeiro F. G., et al., "Timing of endoscopy in cirrhotic patients with acute variceal bleeding: protocol of a multicenter randomized controlled trial", THERAPEUTIC ADVANCES IN GASTROENTEROLOGY, 2024
dc.identifier.doi10.1177/17562848241295452
dc.identifier.issn1756-283X
dc.identifier.pubmed39539489
dc.identifier.urihttps://hdl.handle.net/20.500.12645/39934
dc.identifier.wosWOS:001353975200001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectGastroenteroloji-(Hepatoloji)
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectGastroenterology and Hepatology
dc.subjectHealth Sciences
dc.subjectGastroenteroloji Ve Hepatoloji
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (Med)
dc.subjectGastroenterology & Hepatology
dc.subjectClinical Medicine
dc.subjectClinical Medicine (Med)
dc.subjectHepatoloji
dc.subjectGastroenteroloji
dc.subjectHepatology
dc.subjectGastroenterology
dc.titleTiming of endoscopy in cirrhotic patients with acute variceal bleeding: protocol of a multicenter randomized controlled trial
dc.typearticle
dspace.entity.typePublication
local.avesis.id607840db-a25d-4169-a4ea-2e9109aaf893
local.indexed.atPubMed
local.indexed.atWOS

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