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Intraoperative palpation of sentinel lymph nodes can accurately predict axilla in early breast cancer

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dc.contributor.authorOzkurt, Enver
dc.contributor.authorYardimci, ERKAN
dc.contributor.authorTukenmez, Mustafa
dc.contributor.authorErsoy, YELİZ EMİNE
dc.contributor.authorYilmaz, Ravza
dc.contributor.authorCabioglu, Neslihan
dc.contributor.authorKaranlik, Hasan
dc.contributor.authorKulle, Cemil Burak
dc.contributor.authorMalya, FATMA ÜMİT
dc.contributor.authorOnder, Semen
dc.contributor.authorGucin, ZÜHAL
dc.contributor.authorIgci, Abdullah
dc.contributor.authorOzmen, Vahit
dc.contributor.authorDinccag, Ahmet Sait
dc.contributor.authorMuslumanoglu, Mahmut
dc.contributor.institutionauthorYARDIMCI, ERKAN
dc.contributor.institutionauthorERSOY, YELIZ EMINE
dc.contributor.institutionauthorMALYA, FATMA ÜMİT
dc.contributor.institutionauthorGÜCİN, ZÜHAL
dc.date.accessioned2019-10-05T15:38:27Z
dc.date.available2019-10-05T15:38:27Z
dc.date.issued2019-01-01
dc.description.abstractRecent randomized trials have shown that completion axillary lymph node dissection (ALND) is not required in all patients with a positive sentinel lymph node (SLN) who will receive radiation therapy. Although routine intraoperative pathologic assessment (IPA) becomes unnecessary and less indicated by breast surgeons in the United States and some European countries, it is still widely used all around the world. In this prospective study, the feasibility of intraoperative nodal palpation (INP) as opposed to IPA of the SLN has been analyzed. Between March 2014 and June 2015, 305 patients with clinical T1-2/N0 breast cancer from two different breast clinics (cohort A; [n = 225] and cohort B; [n = 80]) who underwent any breast surgery with sentinel lymph node biopsy (SLNB) were included in this study. Surgeons evaluated the SLNs by manual palpation before sending for IPA, and findings compared with the final pathology. The positive predictive values (PPV) of INP and IPA were 81.8% and 97.9%, respectively, whereas the negative predictive values (NPV) of INP and IPA were 83% and 92.4%. The accuracies of INP and IPA were 82.6% and 94.1%, respectively. If patients with SLNB including micrometastasis were also considered in the final pathologic assessment (FPA) (-) group that would not require a further axillary dissection, the revised NPV of INP and FPA were found to be 92.6% and 98.1%, respectively. The revised accuracy of INP also found to be increase to 86.9%. Our study, which is the only prospective one about palpation of dissected SLNs in the literature, suggests that INP can help to identify patients who do not need ALND, which encourages omitting IPA in cT1-2 N0 breast cancer.
dc.identifier10.1046/j.1365-2133.2000.03808.x
dc.identifier.citationOzkurt E., Yardimci E., Tukenmez M., Ersoy Y. E. , Yilmaz R., Cabioglu N., Karanlik H., Kulle C. B. , Malya F. Ü. , Onder S., et al., -Intraoperative palpation of sentinel lymph nodes can accurately predict axilla in early breast cancer-, BREAST JOURNAL, cilt.25, ss.96-102, 2019
dc.identifier.pubmed30419607
dc.identifier.urihttps://hdl.handle.net/20.500.12645/6366
dc.language.isoen
dc.titleIntraoperative palpation of sentinel lymph nodes can accurately predict axilla in early breast cancer
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameBRITISH JOURNAL OF DERMATOLOGY
local.avesis.id9e8e1e9a-1fc4-47e4-b01c-84b41e372d9a
local.avesis.response6238
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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