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Angiotensin IV improves spatial memory in streptozotocin-induced diabetic rats by reducing oxidative stress and altering BDNF levels

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dc.contributor.authorKILIÇ, AYSU
dc.contributor.authorÜSTÜNOVA, SAVAŞ
dc.contributor.authorELİBOL, BİRSEN
dc.contributor.authorBulut, Huri
dc.contributor.authorMERAL, İSMAİL
dc.contributor.authorSahin, Gulderen
dc.contributor.institutionauthorKILIÇ, AYSU
dc.contributor.institutionauthorÜSTÜNOVA, SAVAŞ
dc.contributor.institutionauthorELİBOL, BİRSEN
dc.contributor.institutionauthorMERAL, İSMAİL
dc.date.accessioned2021-07-06T20:59:10Z
dc.date.available2021-07-06T20:59:10Z
dc.date.issued2021-01-01T00:00:00Z
dc.description.abstractIn this study, we investigated the protective effects of angiotensin IV (Mg IV) on cognitive function in streptozotocin (STZ)-induced diabetic rats. Male Wistar albino rats, were randomly divided into four groups; control (C), diabetes (Dia, 60 mg/kg, STZ, i.p.), Mg IV (5 mu g/kg, s.c.) and Dia+Ang W. The passive avoidance and Morris water maze (MWM) tests were used to evaluate learning and memory performance. Behavioral tests were carried out between 21 and 30 days after the initial Ang IV injection. Hippocampi were dissected and retained for biochemical and Western blot analysis. The Dia group exhibited the poorest behavioral results, while the Dia+Ang W group performed highest on the MWM task. Superoxide dismutase, glutathione peroxidase, and malondialdehyde levels increased significantly in the Dia group compared to Dia+Ang IV. Brain-derived neurotrophic factor (BDNF) and N-methyl-D-aspartate levels were significantly elevated, while levels of GABA(A) significantly decreased, in the Dia+Ang IV group compared to the Dia group. These findings suggest that peripheral administration of Ang IV ameliorated spatial memory in diabetic rats by decreasing hippocampal oxidative stress and BDNF levels.
dc.identifier.citationKILIÇ A., ÜSTÜNOVA S., ELİBOL B., Bulut H., MERAL İ., Sahin G., -Angiotensin IV improves spatial memory in streptozotocin-induced diabetic rats by reducing oxidative stress and altering BDNF levels-, ACTA NEUROBIOLOGIAE EXPERIMENTALIS, cilt.81, sa.2, ss.161-171, 2021
dc.identifier.doi10.21307/ane-2021-015
dc.identifier.pubmed34170263
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29024
dc.identifier.wosWOS:000665479700005
dc.titleAngiotensin IV improves spatial memory in streptozotocin-induced diabetic rats by reducing oxidative stress and altering BDNF levels
dc.typeArticle
dspace.entity.typePublication
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local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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