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Hypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases

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dc.contributor.authorMosztbacher, Dóra
dc.contributor.authorHanák, Lilla
dc.contributor.authorFarkas, Nelli
dc.contributor.authorSzentesi, Andrea
dc.contributor.authorMikó, Alexandra
dc.contributor.authorBajor, Judit
dc.contributor.authorSarlós, Patrícia
dc.contributor.authorCzimmer, József
dc.contributor.authorVincze, ron
dc.contributor.authorHegyi, Péter Jenő
dc.contributor.authorErőss, Bálint
dc.contributor.authorTakács, Tamás
dc.contributor.authorCzakó, László
dc.contributor.authorNémeth, Balázs Csaba
dc.contributor.authorIzbéki, Ferenc
dc.contributor.authorHalász, Adrienn
dc.contributor.authorGajdán, László
dc.contributor.authorHamvas, József
dc.contributor.authorPapp, Mária
dc.contributor.authorFöldi, Ildikó
dc.contributor.authorFehér, Krisztina Eszter
dc.contributor.authorVarga, Márta
dc.contributor.authorCsefkó, Klára
dc.contributor.authorTörök, Imola
dc.contributor.authorFarkas, Hunor Pál
dc.contributor.authorMickevicius, Artautas
dc.contributor.authorMaldonado, Elena Ramirez
dc.contributor.authorSallinen, Ville
dc.contributor.authorNovák, János
dc.contributor.authorİNCE, ALİ TÜZÜN
dc.contributor.authorGaleev, Shamil
dc.contributor.authorBod, Barnabás
dc.contributor.authorSümegi, János
dc.contributor.authorPencik, Petr
dc.contributor.authorDubravcsik, Zsolt
dc.contributor.authorIllés, Dóra
dc.contributor.authorGódi, Szilárd
dc.contributor.authorKui, Balázs
dc.contributor.authorMárta, Katalin
dc.contributor.authorPécsi, Dániel
dc.contributor.authorVarjú, Péter
dc.contributor.authorSzakács, Zsolt
dc.contributor.authorDarvasi, Erika
dc.contributor.authorPárniczky, Andrea
dc.contributor.authorHegyi, Péter
dc.contributor.institutionauthorİNCE, ALİ TÜZÜN
dc.date.accessioned2020-06-04T20:59:10Z
dc.date.available2020-06-04T20:59:10Z
dc.date.issued2020-01-01T00:00:00Z
dc.description.abstractBackground Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). It has been shown that hypertriglyceridemia aggravates the severity and related complications of AP; however, detailed analyses of large cohorts are contradictory. Our aim was to investigate the dose-dependent effect of hypertriglyceridemia on AP. Methods AP patients over 18 years old who underwent triglyceride measurement within the initial three days were included into our cohort analysis from a prospective international, multicenter AP registry operated by the Hungarian Pancreatic Study Group. Data on 716 AP cases were analyzed. Six groups were created based on the highest triglyceride level (<1.7 mmol/l, 1.7–2.19 mmol/l, 2.2–5.59 mmol/l, 5.6–11.29 mmol/l, 11.3–22.59 mmol/l, ≥22.6 mmol/l). Results Hypertriglyceridemia (≥1.7 mmol/l) presented in 30.6% of the patients and was significantly and dose-dependently associated with younger age and male gender. In 7.7% of AP cases, hypertriglyceridemia was considered as a causative etiological factor (≥11.3 mmol/l); however, 43.6% of these cases were associated with other etiologies (alcohol and biliary). Hypertriglyceridemia was significantly and dose-dependently related to obesity and diabetes. The rates of local complications and organ failure and maximum CRP level were significantly and dose-dependently raised by hypertriglyceridemia. Triglyceride above 11.3 mmol/l was linked to a significantly higher incidence of moderately severe AP and longer hospital stay, whereas triglyceride over 22.6 mmol/l was significantly associated with severe AP as well.en
dc.identifier.citationMosztbacher D., Hanák L., Farkas N., Szentesi A., Mikó A., Bajor J., Sarlós P., Czimmer J., Vincze r., Hegyi P. J. , et al., -Hypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases-, Pancreatology, 2020
dc.identifier.doi10.1016/j.pan.2020.03.018
dc.identifier.pubmed32402696
dc.identifier.scopus85084505077
dc.identifier.urihttps://hdl.handle.net/20.500.12645/18039
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1424390320301265?via%3Dihub
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.holderPancreatology
dc.subjectAcute pancreatitis
dc.titleHypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases
dc.typeArticle
dspace.entity.typePublication
local.avesis.id76b2a7f5-6e62-48bf-9de1-7d5209636c82
local.publication.isinternational1
relation.isAuthorOfPublication6daa6ab7-ee45-4f50-9e71-e831046b6462
relation.isAuthorOfPublication.latestForDiscovery6daa6ab7-ee45-4f50-9e71-e831046b6462
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