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Vitamin D-Dependent Rickets: Eight Cases

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dc.contributor.authorCesur, YAŞAR
dc.contributor.authorYuca, Sevil Ari
dc.contributor.authorBektas, Selcuk
dc.contributor.authorYilmaz, Cahide
dc.contributor.authorDulger, Haluk
dc.contributor.authorTemel, Hayrettin
dc.contributor.institutionauthorCESUR, YAŞAR
dc.date.accessioned2020-10-30T00:02:18Z
dc.date.available2020-10-30T00:02:18Z
dc.date.issued2016-01-01T00:00:00Z
dc.description.abstractObjective: Vitamin D is essential for bone development and health, and deficiency resulting in rickets and skeletal deformities is seen mainly during rapid growth. Hereditary vitamin D dependent rickets type I and type II rickets is a very rare form of rickets, characterized by 1-alpha-hydroxylase deficiency or end-organ resistance to vitamin D. We aimed to investigate, clinical and laboratory characteristics of eight cases with Vitamin D-dependent rickets (VDRR). Method: The mean age of patients during diagnosis was 2.6 years. Excluding one patient, others were males (87.5%). Results: Mean laboratory values during referral was calcium 7.5 +/- 1,5 mg/dl, phosphorus 4 +/- 1.2 mg/dl, alkaline phosphatase (ALP) 1679 +/- 641 U/L and parathyroid hormone (PTH) 524 +/- 498 pg/ml. Patients received 1.2 mu g/kg/day calcitriol. During follow-ups serum ALP and PTH values of patients turned to normal levels. Conclusion: In rickets, cases with persistent increased serum ALP and PTH levels it will be appropriate to investigate serum 25 (OH) D levels in cases diagnosed with vitamin D-dependent rickets even though hypocalcaemia is absent. Administration of adequate doses of calcitriol in some cases is able to clinical and laboratory values return to normal.
dc.identifier.citationCesur Y., Yuca S. A. , Bektas S., Yilmaz C., Dulger H., Temel H., -Vitamin D-Dependent Rickets: Eight Cases-, EUROPEAN JOURNAL OF GENERAL MEDICINE, cilt.13, ss.16-20, 2016
dc.identifier.doi10.15197/ejgm.01464
dc.identifier.scopus84955491155
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27096
dc.identifier.wosWOS:000382752700003
dc.titleVitamin D-Dependent Rickets: Eight Cases
dc.typeArticle
dspace.entity.typePublication
local.avesis.ide868e687-d621-491d-a315-86f663eb772d
local.publication.isinternational1
relation.isAuthorOfPublicationddd881a5-c7cb-41e5-b4e1-0693a98a0d29
relation.isAuthorOfPublication.latestForDiscoveryddd881a5-c7cb-41e5-b4e1-0693a98a0d29
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