Design and Characterization of Herbal Actives Included Topical Nanoemulgels for Varicose Disease

Abstract

The aim of this study is to prepare a nanoemulgel for topical application containing Lavandula angustifolia L. essential oil has anti-inflammatory, analgesic and antioxidant effects in combination with vasoconstrictor effective Punica granatum L. fruit peel extract as phytoactive components due to their major phytochemicals. Essential oil and extract take place in the inner and outher phases of nanoemulgel respectively. For this purpose, firstly, quantitative content determination was made by LC-HRMS analysis of standardized vegetable essential oil and extract, then twelve nanoemulsion formulations were prepared and droplet size and polydispersity index were determined. According to the results, four successful formulations were selected and droplet size, PDI, zeta potential, pH and electrical conductivity measurements were made. The formulations were subjected to centrifuge test and nanoemulsion stability was evaluated, the most successful formulation was selected with 1% lavender essential oil and 9.6% pomegranate peel extract, and the gelling process was performed with the addition of 0.5% acrylic acid to the outer phase. The pH, electrical conductivity, viscosity, spreadability and texturing properties of the obtained nanoemulgel were examined, and it was decided that it was a promising formulation in accordance with the skin-compatible pH, non-Newtonian pseudoplastic flow, successful texture and spreadability properties, and advanced performance studies were conducted.