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Effects of Cichorium intybus on serum oxidative stress, liver and kidney volume, and cyclin B1 and Bcl-2 levels in the brains of rats with ethanol induced damage

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dc.contributor.authorErkeç, Özlem Ergül
dc.contributor.authorArıhan, Okan
dc.contributor.authorÇölçimen, Neşe
dc.contributor.authorKara, Mehmet
dc.contributor.authorKaratas, Ersin
dc.contributor.authorDemir, Halit
dc.contributor.authorRağbetli, Murat Çetin
dc.date.accessioned2020-10-22T15:58:43Z
dc.date.available2020-10-22T15:58:43Z
dc.date.issued2018-01-01T00:00:00Z
dc.description.abstractWe investigated the effects of an aqueous root extract of Cichonum iniyhus on Bcl-2 and cyclin B1 levels in the brain, kidney and liver volumes and changes of serum total antioxidant status (TAS) and total oxidant status (TOS) levels in ethanol induced damage in rats. The rats were divided into five groups non-treated controls (C), maltodextrin in tap water treated (MD), 6.4% ethanol in tap water treated (ET), Cichorium iniyhus + maltodextrin in tap water treated (CI+MD), and Cichorium intybus + 6.4% ethanol in tap water treated (CI+ET). Rats in the CI+MD and CI+ET groups were treated with 200 mg/kg water extract of Cichorium intybus. Chronic ethanol aMDinistration significantly increased cyclin B1 and decreased Bcl-2 levels in the brain and significantly decreased TAS values, increased TOS values of serum and significantly decreased kidney volume in the ET group. There was no significant difference in the liver volume or liver cell count. Our data rev ealed that ethanol aMDinistration induces an overexpression of cyclin B1 and decreases levels of Bcl-2 in rat brains and induced oxidative stress in the blood. C. intybus treatment possessed a partial amelioration effect on cyclin B1 levels and TAS values.
dc.identifier.citationErkeç Ö. E. , Arıhan O., Çölçimen N., Kara M., Karatas E., Demir H., Rağbetli M. Ç. , -Effects of Cichorium intybus on serum oxidative stress, liver and kidney volume, and cyclin B1 and Bcl-2 levels in the brains of rats with ethanol induced damage-, CELLULAR AND MOLECULAR BIOLOGY, cilt.64, ss.30-35, 2018
dc.identifier.doi10.14715/cmb/2018.64.7.6
dc.identifier.pubmed29974843
dc.identifier.scopus85048592181
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23774
dc.identifier.wosWOS:000439020900006
dc.titleEffects of Cichorium intybus on serum oxidative stress, liver and kidney volume, and cyclin B1 and Bcl-2 levels in the brains of rats with ethanol induced damage
dc.typeArticle
dspace.entity.typePublication
local.avesis.id5b8855fd-dca6-41a4-8b09-db5830001a93
local.publication.isinternational1
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