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Synthesis, Anticholinesterase, Antioxidant, and Anti-Aflatoxigenic Activity of Novel Coumarin Carbamate Derivatives

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dc.contributor.authorKURT, Belma Zengin
dc.contributor.authorGazioglu, IŞIL
dc.contributor.authorKANDAS, Nur Ozten
dc.contributor.authorSonmez, Fatih
dc.contributor.institutionauthorZENGİN KURT, BELMA
dc.contributor.institutionauthorGAZİOĞLU, IŞIL
dc.date.accessioned2019-10-05T12:46:58Z
dc.date.available2019-10-05T12:46:58Z
dc.date.issued2018-04-17
dc.description.abstractNew coumarin derivatives with the carbamate moiety were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 4-methyl-2-oxo-2H-chromen-7-yl cycloheptylcarbamate (4h) showed the strongest inhibition against AChE with IC50 values of 2.30 mu M, and 2-oxo-2H-chromen-7-yl-(cyclohexylmethyl)carbamate (4c) and 4-methyl-2-oxo-2H-chromen-7-yl-(cyclohexylmethyl)carbamate (4g) were found to be the most potent BuChE inhibitors with IC50 value of 0.003 mu M and 0.004 mu M, respectively. Moreover antioxidant, anti-aflatoxigenic activities, protective effects against aflatoxin-B1 (AFB1) in H4IIE-C3 cells and effects on glutathione s-transferase of the synthesized compounds were investigated. The synthesized coumarin carbamates inhibited AFB1 in H4IIE-C3 cells. Western blot analyses confirmed that GST alpha protein was induced in cells treated with coumarin carbamates and AFB1. These results showed that the synthesized coumarin carbamates possess a potent protective effect against AFB1.
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier10.5262/tndt.2013.1003.06
dc.identifier.citationKURT B. Z. , Gazioglu I., KANDAS N. O. , Sonmez F., -Synthesis, Anticholinesterase, Antioxidant, and Anti-Aflatoxigenic Activity of Novel Coumarin Carbamate Derivatives-, CHEMISTRYSELECT, cilt.3, ss.3978-3983, 2018
dc.identifier.doi10.1002/slct.201800142
dc.identifier.scopus85045667230
dc.identifier.urihttps://hdl.handle.net/20.500.12645/559
dc.identifier.wosWOS:000430386800016
dc.language.isoen
dc.titleSynthesis, Anticholinesterase, Antioxidant, and Anti-Aflatoxigenic Activity of Novel Coumarin Carbamate Derivatives
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTurkish Nephrology, Dialysis and Transplantation Journal
local.avesis.id0ae92c10-dbbd-480f-b53a-221026031ded
local.avesis.response429
local.publication.isinternational1
relation.isAuthorOfPublication3fd265b5-fdd8-4c56-949b-deb0303c3db7
relation.isAuthorOfPublication336380d2-70ee-496d-a002-08059f9da500
relation.isAuthorOfPublication.latestForDiscovery336380d2-70ee-496d-a002-08059f9da500
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