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Herbal Haemorrhoidal Cream for Haemorrhoids

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dc.contributor.authorGurel, Ebru
dc.contributor.authorUstunova, SAVAŞ
dc.contributor.authorErgin, Bulent
dc.contributor.authorTan, Nur
dc.contributor.authorCaner, Metin
dc.contributor.authorTortum, Osman
dc.contributor.authorDemirci-Tansel, Cihan
dc.contributor.institutionauthorÜSTÜNOVA, SAVAŞ
dc.date.accessioned2020-10-29T22:22:10Z
dc.date.available2020-10-29T22:22:10Z
dc.date.issued2013-10-31T00:00:00Z
dc.description.abstractAlthough hemorrhoids are one of the most common diseases in the world, the exact etiology underlying the development of hemorrhoids is not clear. Many different ointments are currently used to treat hemorrhoids; however, there is little evidence of the efficacy of these treatments to support their use. The aim of this study was to compare different herbal creams used for the treatment of hemorrhoids. Twenty-eight male Wistar albino rats, 6-8 weeks old and weighing 160-180 g, were used in this study as 1-control, 2-croton oil, 3-croton oil+fig leaves+artichoke leaves+walnut husks and 4-croton oil+fig leaves+artichoke leaves+walnut husks+horse chestnut fruit. After 3 days of croton oil application, rats were treated with 0.1 ml of cream or saline twice a day for 15 days by syringe. Tissue and blood samples were collected for histological, immunohistochemical and biochemical studies. Statistical significance was determined using one-way ANOVA followed by Tukey-s multiple comparison tests. Croton oil administration resulted in severe inflammation. The third group showed partial improvement in inflammation; however, the greatest degree of improvement was seen in the fourth group, and some recovered areas were observed. Myeloperoxidase immunoreactivity was found to be decreased in the third and fourth groups compared to the second group. Additionally, biochemical analyses (Myeloperoxidase, Malondyaldehyde, nitrate/nitrite and nitrotyrosine levels and Superoxide Dismutase activity) were in agreement with the histological and immunohistochemical results. In conclusion, croton oil causes inflammation in the anal area and results in hemorrhoids. Treatment with our herbal hemorrhoid creams demonstrated anti-inflammatory and anti-oxidant effects in this model.
dc.identifier.citationGurel E., Ustunova S., Ergin B., Tan N., Caner M., Tortum O., Demirci-Tansel C., -Herbal Haemorrhoidal Cream for Haemorrhoids-, CHINESE JOURNAL OF PHYSIOLOGY, cilt.56, ss.253-262, 2013
dc.identifier.doi10.4077/cjp.2013.bab127
dc.identifier.scopus84884683594
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26572
dc.identifier.wosWOS:000326767200002
dc.titleHerbal Haemorrhoidal Cream for Haemorrhoids
dc.typeArticle
dspace.entity.typePublication
local.avesis.idaef64401-d539-4af7-bdd7-6df9dc6df3d1
local.publication.isinternational1
relation.isAuthorOfPublicationbebec550-3712-466a-8e2d-8f90006e62f6
relation.isAuthorOfPublication.latestForDiscoverybebec550-3712-466a-8e2d-8f90006e62f6
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