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Prevalence of erectile dysfunction in male survivors of cancer: a systematic review and meta-analysis of cross-sectional studies.

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dc.contributor.authorPizzol, Damiano
dc.contributor.authorXiao, Tao
dc.contributor.authorSmith, Lee
dc.contributor.authorSánchez, Guillermo F López
dc.contributor.authorGarolla, Andrea
dc.contributor.authorParris, Christopher
dc.contributor.authorBarnett, Yvonne
dc.contributor.authorIlie, Petre Cristian
dc.contributor.authorSoysal, PINAR
dc.contributor.authorShin, Jae Il
dc.contributor.authorTully, Mark A
dc.contributor.authorYang, Lin
dc.contributor.authorVeronese, Nicola
dc.contributor.authorGrabovac, Igor
dc.contributor.institutionauthorSOYSAL, PINAR
dc.date.accessioned2021-05-01T20:59:13Z
dc.date.available2021-05-01T20:59:13Z
dc.date.issued2021-04-29T00:00:00Z
dc.description.abstractBackground: Prevalence of erectile dysfunction (ED) in male survivors of cancer across cancer types has not been systematically analysed. Aim: To estimate the prevalence of ED in all types of cancer and identify characteristics associated with ED in survivors of cancer. Design and setting: Systematic review and meta-analysis (MA) of cross-sectional studies. Method: MEDLINE, CINAHL, PsycINFO, and EMBASE were searched, targeting reports published from inception to 1 February 2020. All retrospective or prospective studies reporting prevalence of ED in male patients with cancer and using a validated tool for detection of ED were included. A random-effects MA model was used to pool prevalence of ED as absolute estimates at three different stages, that is, 'healthy', 'at diagnosis', and 'after treatment'. A univariate MA regression including the three-level group variable as the only independent variable was used to assess the difference in ED prevalence across the three groups. Further MAs were conducted for studies involving patients at diagnosis and after treatment, and statistical inferences were made with setting for multiple testing controlling for a false discovery rate (FDR) <0.05. Results: In total, 1301 studies were assessed for inclusion. Of these, 141 were potentially eligible and subsequently scrutinised in full text. Finally, 43 studies were included with a total of 13 148 participants. Overall, pooled data of the included studies showed an ED prevalence of 40.72% (95% confidence interval [CI] = 31.80 to 50.29) in patients with cancer, with prevalences of 28.60% (95% CI = 12.10 to 53.83) at time of diagnosis and 42.70% (95% CI = 32.97 to 53.03) after treatment, with significant difference between these two stages and across cancer locations, controlling for an FDR <0.05. Conclusion: Erectile dysfunction was particularly high in male survivors of cancer and was associated with cancer treatment, cancer site, and age.
dc.identifier.citationPizzol D., Xiao T., Smith L., Sánchez G. F. L. , Garolla A., Parris C., Barnett Y., Ilie P. C. , Soysal P., Shin J. I. , et al., -Prevalence of erectile dysfunction in male survivors of cancer: a systematic review and meta-analysis of cross-sectional studies.-, The British journal of general practice : the journal of the Royal College of General Practitioners, cilt.71, 2021
dc.identifier.doi10.3399/bjgp20x714197
dc.identifier.pubmed33926885
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28824
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titlePrevalence of erectile dysfunction in male survivors of cancer: a systematic review and meta-analysis of cross-sectional studies.
dc.typeArticle
dspace.entity.typePublication
local.avesis.idcfec73e3-1e08-46d1-95e7-3a015bf5a9aa
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication0e36986e-d71d-4579-a395-877af097ade5
relation.isAuthorOfPublication.latestForDiscovery0e36986e-d71d-4579-a395-877af097ade5
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relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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