Publication:
Sustainable signal processing spectrophotometric analysis of candesartan, hydrochlorothiazide, and amlodipine: Green methods aligned with global sustainability goals

dc.contributor.authorLotfy H. M.
dc.contributor.authorTIRIS G.
dc.contributor.authorGenc A. A.
dc.contributor.authorObaydo R. H.
dc.contributor.authorERK N.
dc.date.accessioned2025-04-30T21:50:22Z
dc.date.issued2025-10-05
dc.description.abstractGreen Analytical Chemistry (GAC) aims to create eco-friendly methods for pharmaceutical analysis, with a focus on quality control. This study focuses on the simultaneous quantification of candesartan (CAN), hydrochlorothiazide (HCT), and amlodipine (AML) in a triple medication using two green spectrophotometric techniques. The study incorporates mathematical manipulation approaches to extract the parent spectrum of each drug component. These integrated methods address the problem of spectral signal overlap without requiring prior separation, utilizing a factorized spectrum (FS), which is notable for its capacity to assess the specified drugs in the mixture and retrieve their original zero-order spectra it is distinctive for its ability to evaluate the mentioned drugs within the mixture and recover their initial zero-order spectra. The first integrated resolution technique, the Integrated signal processing plan (ISPP-D0), was applied to the mixture\"s zero-order spectrum, including successive manipulation of three methods: extended absorbance difference, absorbance resolution, and spectrum subtraction. The second integrated resolution technique is the Integrated signal processing plan (ISPP-R)via ratio spectrum of the mixture, which includes successive manipulation of three methods: dual amplitude difference, ratio extraction, and spectrum subtraction. The proposed methods were validated and assessed following the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines, showing linear concentration ranges of 5.0–35.0 µg/mL for CAN at 254.0 nm, 2.0–20.0 µg/mL for HCT at 270.0 nm, and 5.0–35.0 µg/mL for AML at 240.0 nm. The specificity was evaluated by accurately and precisely determining the concentrations of the three drugs in their synthetic blends and single-tablet pharmaceutical formulation. The findings were statistically analyzed against the official results using the F-test and Student\"s t-test, indicating no notable differences. These UV spectrophotometric techniques align with green analytical chemistry (GAC) and white analytical chemistry (WAC) principles, supporting the United Nations Sustainable Development Goals (UNSDGs). These integrated analytical techniques for drug analysis offer enhanced precision and efficiency, enabling the retrieval of zero-order spectra that serve as unique fingerprints for each analyte. These advancements simplify the identification process, improve accuracy, and ensure reliable results, making them invaluable in pharmaceutical research and quality control.
dc.identifier.citationLotfy H. M., TIRIS G., Genc A. A., Obaydo R. H., ERK N., "Sustainable signal processing spectrophotometric analysis of candesartan, hydrochlorothiazide, and amlodipine: Green methods aligned with global sustainability goals", Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, cilt.338, 2025
dc.identifier.doi10.1016/j.saa.2025.126157
dc.identifier.issn1386-1425
dc.identifier.pubmed40209449
dc.identifier.scopus105002248085
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105002248085&origin=inward
dc.identifier.urihttps://hdl.handle.net/20.500.12645/40584
dc.identifier.volume338
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFizik
dc.subjectAtom ve Molekül Fiziği
dc.subjectKimya
dc.subjectAnalitik Kimya
dc.subjectFizikokimya
dc.subjectSpektroskopi
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectPhysics
dc.subjectAtomic and Molecular Physics
dc.subjectChemistry
dc.subjectAnalytical Chemistry
dc.subjectPhysical Chemistry
dc.subjectSpectroscopy
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik Bilişim Ve Teknoloji (Eng)
dc.subjectTemel Bilimler (Sci)
dc.subjectMühendislik
dc.subjectAletler & Gösterim
dc.subjectKimya Analitik
dc.subjectFizik Atomik Moleküler Ve Kimyasal
dc.subjectEngineering Computing & Technology (Eng)
dc.subjectNatural Sciences (Sci)
dc.subjectEngineering
dc.subjectInstruments & Instrumentation
dc.subjectChemistry Analytical
dc.subjectPhysics Atomic Molecular & Chemical
dc.subjectFizik Bilimleri
dc.subjectAtom ve Moleküler Fizik ve Optik
dc.subjectEnstrümantasyon
dc.subjectPhysical Sciences
dc.subjectAtomic and Molecular Physics, and Optics
dc.subjectInstrumentation
dc.subjectAmlodipine
dc.subjectCandesartan
dc.subjectFactorized spectrum and UV spectrophotometry
dc.subjectHydrochlorothiazide
dc.subjectUnited Nations Sustainable Development Goals (UNSDGs)
dc.titleSustainable signal processing spectrophotometric analysis of candesartan, hydrochlorothiazide, and amlodipine: Green methods aligned with global sustainability goals
dc.typearticle
dspace.entity.typePublication
local.avesis.id3e31a309-75bc-4fc9-9c2b-0e79e5fb1ae7

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