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Acute Myocarditis and Eculizumab Caused Severe Cholestasis in a 17-Month-Old Child Who Has Hemolytic Uremic Syndrome Associated with Shiga Toxin-Producing Escherichia coli

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dc.contributor.authorYEŞİLBAŞ, Osman
dc.contributor.authorYozgat, Can Yilmaz
dc.contributor.authorAKINCI, NURVER
dc.contributor.authorSÖNMEZ, ŞİRİN
dc.contributor.authorTEKİN, ESER
dc.contributor.authorTALEBAZADEH, FARAZ
dc.contributor.authorJAFAROV, UZEYİR
dc.contributor.authorOTÇU TEMUR, Hafize
dc.contributor.authorYOZGAT, YILMAZ
dc.contributor.institutionauthorYEŞİLBAŞ, OSMAN
dc.contributor.institutionauthorAKINCI, NURVER
dc.contributor.institutionauthorSÖNMEZ, ŞİRİN
dc.contributor.institutionauthorTEKİN, ESER
dc.contributor.institutionauthorTALEBAZADEH, FARAZ
dc.contributor.institutionauthorJAFAROV, UZEYİR
dc.contributor.institutionauthorOTÇU TEMUR, HAFİZE
dc.contributor.institutionauthorYOZGAT, YILMAZ
dc.date.accessioned2021-08-24T20:59:13Z
dc.date.available2021-08-24T20:59:13Z
dc.date.issued2021-09-01T00:00:00Z
dc.description.abstractCardiovascular involvement is uncommon in pediatric patients with hemolytic uremic syndrome associated with Shiga toxin-producing Escherichia coli (STEC-HUS). In this case report we presented a case of 17-month-old toddler who had a sporadic type of STEC-HUS complicated by acute myocarditis. The patient was successfully treated by a single dose of eculizumab after six doses of therapeutic plasma exchange (TPE) were inefficient to prevent the cardiac complication. Hepatotoxicity was observed after a single dose of eculizumab. Hepatic and cholestatic enzyme levels slowly returned to normal within 6 months. To the best of our knowledge, this is the first case of myocarditis/cardiomyopathy treated with eculizumab in STEC-HUS. This case illustrates the need for vigilance regarding myocardial involvement and eculizumab-induced hepatotoxicity in STEC-HUS.
dc.identifier.citationYEŞİLBAŞ O., Yozgat C. Y. , AKINCI N., SÖNMEZ Ş., TEKİN E., TALEBAZADEH F., JAFAROV U., OTÇU TEMUR H., YOZGAT Y., -Acute Myocarditis and Eculizumab Caused Severe Cholestasis in a 17-Month-Old Child Who Has Hemolytic Uremic Syndrome Associated with Shiga Toxin-Producing Escherichia coli-, JOURNAL OF PEDIATRIC INTENSIVE CARE, cilt.10, sa.3, ss.216-220, 2021
dc.identifier.doi10.1055/s-0040-1713111
dc.identifier.pubmed34395040
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29269
dc.identifier.wosWOS:000683101400008
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleAcute Myocarditis and Eculizumab Caused Severe Cholestasis in a 17-Month-Old Child Who Has Hemolytic Uremic Syndrome Associated with Shiga Toxin-Producing Escherichia coli
dc.typeArticle
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