Publication:
Clinical and histopathological improvement of scleromyxedema-induced microstomia after hyaluronidase injection

Simple item page
dc.contributor.authorAKASLAN, TAHSİN ÇAĞDAŞ
dc.contributor.authorYILDIZ, PELİN
dc.contributor.authorONSUN, Nahide
dc.contributor.institutionauthorAKASLAN, TAHSİN ÇAĞDAŞ
dc.contributor.institutionauthorYILDIZ, PELİN
dc.contributor.institutionauthorONSUN, NAHIDE
dc.date.accessioned2022-05-17T20:59:36Z
dc.date.available2022-05-17T20:59:36Z
dc.date.issued2022-05-01T00:00:00Z
dc.description.abstractIntroduction Scleromyxedema is a rare primary cutaneous mucinosis characterized by numerous firm, waxy, confluent papules. Recently, intravenous immunoglobulin (IVIG) is accepted by many authors as the first-line treatment option for severe cases. We report a 69-year-old male patient who has been suffering from scleromyxedema, with reduced mouth opening. He has been on a high-dose IVIG regime for 5 years. Methods The patient stated that he had difficulty in wearing and removing his dentures because of reduced mouth opening lately. Before considering to add any other immunosuppressants to his regime, we injected 1500 IU of hyaluronidase in total in one session periorally. The patient has been told open his mouth maximum and photographs have been taken before injections and after one month. We used a photo measurement application when evaluating microstomia to increase accuracy. We also took punch biopsies in order to evaluate effect of hyaluronidase histopathologically before and one month after injections. Results One month later, he was able to reattach and remove his dentures without adding any adjuvant immunosuppressants other than hyaluronidase. Mouth opening was increased in measurements and histopathologically, mucin deposition, fibroblastic proliferation, and perivascular lymphocytic infiltration were decreased. Conclusions We think hyaluronidase is a safe, easily accessible, and effective treatment option for microstomia caused by scleromyxedema.
dc.identifier.citationAKASLAN T. Ç. , YILDIZ P., ONSUN N., -Clinical and histopathological improvement of scleromyxedema-induced microstomia after hyaluronidase injection-, JOURNAL OF COSMETIC DERMATOLOGY, 2022
dc.identifier.doi10.1111/jocd.15007
dc.identifier.pubmed35441782
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30623
dc.identifier.wosWOS:000792646000001
dc.titleClinical and histopathological improvement of scleromyxedema-induced microstomia after hyaluronidase injection
dc.typeArticle
dspace.entity.typePublication
local.avesis.id809674a0-dd44-4bc2-b027-84b3269d6f01
local.publication.isinternational1
relation.isAuthorOfPublication312d447b-fcec-493b-a3e8-3cc33e7ca7fe
relation.isAuthorOfPublication4c9a734d-36ee-4704-9e15-7012fd2ca3fb
relation.isAuthorOfPublication1ebc9a95-ecf2-4c81-9f74-3c5fb32a9406
relation.isAuthorOfPublication.latestForDiscovery1ebc9a95-ecf2-4c81-9f74-3c5fb32a9406
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
J of Cosmetic Dermatology - 2022 - Akaslan - Clinical and histopathological improvement of scleromyxedema‐induced.pdf
Size:
2.31 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Yayınlar - Eserler