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Osteocalcin, Cortisol Levels, and Bone Mineral Density in Prepubertal Children with Asthma Treated with Long-Term Fluticasone Propionate

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dc.contributor.authorOzkaya, EMİN
dc.contributor.authorNURSOY, Mustafa A.
dc.contributor.authorErenberk, UFUK
dc.contributor.authorCakir, ERKAN
dc.contributor.institutionauthorÖZKAYA, EMİN
dc.contributor.institutionauthorNURSOY, MUSTAFA ATİLLA
dc.contributor.institutionauthorUZUNER, SELÇUK
dc.contributor.institutionauthorERENBERK, UFUK
dc.contributor.institutionauthorÇAKIR, ERKAN
dc.date.accessioned2019-10-05T13:29:42Z
dc.date.available2019-10-05T13:29:42Z
dc.date.issued2012-01-01
dc.description.abstractAims: The objective of this study is to determine the effects of the long-term treatment with inhaled fluticasone propionate on osteocalcin, cortisol levels, and bone mineral status in children with asthma. Methods: This cross-sectional study examined 230 prepubertal children with asthma (aged 6–11) who had intermittently used inhaled fluticasone propionate for at least 5 years at a mean daily dose of 200 μg (range: 200-350 μg). Serum osteocalcin, cortisol, and bone mineral density (BMD) of the lumbar spine were obtained from each participant. The control group consisted of gender- and age-matched children (n = 170) who were newly diagnosed with asthma and who were not being treated with corticosteroid. Results: The average age (± SEM) was 8.9 ± 0.7 years, their mean (± SEM) daily steroid dose was 180.3 ± 55.0 μg, with 236.5 ± 17.2 g total steroid use during treatment. Between the study and the control groups, no significant differences were observed in cortisol, osteocalcin levels, and BMD (p > 0.05). Conclusion: Long-term treatment with inhaled fluticasone propionate (100 μg twice daily) revealed no negative effects on serum osteocalcin, cortisol levels, and BMD in children with asthma.en
dc.identifier10.1038/sj.ijir.3901530
dc.identifier.citationOzkaya E., NURSOY M. A. , Uzuner S., Erenberk U., Cakir E., -Osteocalcin, Cortisol Levels, and Bone Mineral Density in Prepubertal Children with Asthma Treated with Long-Term Fluticasone Propionate-, HORMONE RESEARCH IN PAEDIATRICS, cilt.77, ss.351-357, 2012
dc.identifier.doi10.1159/000338785
dc.identifier.pubmed22760032
dc.identifier.scopus84864334733
dc.identifier.urihttps://hdl.handle.net/20.500.12645/2214
dc.identifier.urihttps://www.karger.com/Article/FullText/338785
dc.identifier.wosWOS:000306949200002
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectAsthma
dc.titleOsteocalcin, Cortisol Levels, and Bone Mineral Density in Prepubertal Children with Asthma Treated with Long-Term Fluticasone Propionate
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameInternational journal of impotence research
local.avesis.id35b5644a-1321-4ae6-b291-67240dac7d5c
local.avesis.response2084
local.publication.isinternational1
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relation.isAuthorOfPublicatione78a6738-63a5-4f48-aac4-24de67b736cf
relation.isAuthorOfPublication5a52edc0-0365-409d-88ce-c6afe0470201
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relation.isAuthorOfPublication.latestForDiscovery548bd03a-cc9a-4b60-9886-1787eb5f6a4d
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