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Can COVID-19 induce glioma tumorogenesis through binding cell receptors?

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dc.contributor.authorKhan, Imran
dc.contributor.institutionauthorKHAN, IMRAN
dc.date.accessioned2021-01-12T20:59:07Z
dc.date.available2021-01-12T20:59:07Z
dc.date.issued2020-06-01T00:00:00Z
dc.description.abstractThe outbreak of Novel Coronavirus 2019 (COVID-19) represents a global threat to the public healthcare. The viral spike (S) glycoprotein is the key molecule for viral entry through interaction with angiotensin converting enzyme 2 (ACE2) receptor molecules present on the cell membranes. Moreover, it has been established that COVID-19 interacts and infects brain cells in humans via ACE2. Therefore in the light of these known facts we hypothesized that viral S protein molecule may bind to the other overexpressed receptor molecules in glioma cells and may play some role in glioma tumorogenesis. Thus we leverage docking analysis (HEX and Z-DOCK) between viral S protein and epidermal growth factor receptors (EGFR), vascular endothelial growth factor receptors (VEGFR) and hepatocyte growth factor receptors (HGFR/c-MET) to investigate the oncogenic potential of COVID-19. Our findings suggested higher affinity of Viral S protein towards EGFR and VEGFR. Although, the data presented is preliminary and need to be validated further via molecular dynamics studies, however it paves platform to instigate further investigations on this aspect considering the aftermath of COVID-19 pandemic in oncogenic perspective.
dc.identifier.citationKhan I., -Can COVID-19 induce glioma tumorogenesis through binding cell receptors?-, Medical Hypotheses, cilt.144, no.110009, ss.1-2, 2020
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27878
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0306987720314778?via%3Dihub
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.titleCan COVID-19 induce glioma tumorogenesis through binding cell receptors?
dc.typeArticle
dspace.entity.typePublication
local.avesis.id961b1ec5-61e1-4981-ae26-37cf3f440a65
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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