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Quantitative determination of some phenolics in Origanum laevigatum Boiss. extracts via validated LC-MS/MS method and antioxidant activity

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dc.contributor.authorCarikci, Sema
dc.contributor.authorKilic, Turgut
dc.contributor.authorOzer, Zuleyha
dc.contributor.authorDirmenci, Tuncay
dc.contributor.authorARABACI, TURAN
dc.contributor.authorGoren, AHMET CEYHAN
dc.contributor.institutionauthorGÖREN, AHMET CEYHAN
dc.date.accessioned2019-10-05T21:22:52Z
dc.date.available2019-10-05T21:22:52Z
dc.date.issued2018-07-01
dc.description.abstractIn this study, quantities of some phenolics; caffeic acid, (E)-ferulic acid, rosmarinic acid, chlorogenic acid, fumaric acid, gallic acid, pyrogallol and vanillin in the directly methanol (M1), chloroform (C), acetone (Ac) and methanol (M2) extratcs obtained from Origanum laevigatum Boiss. from Turkey were investigated via liquid chromatography and tandem mass spectrometry (LC-MS/MS). Curcumin was used as an internal standard. Caffeic acid, chlorogenic acid, rosmarinic acid and gallic acid were determined as the most abundant phenolic acids in the studied extracts using LC-MS/MS. In LC-MS/MS measurements relative standard deviations (RSD %) for caffeic acid, (E)-ferulic acid, rosmarinic acid, chlorogenic acid, fumaric acid, gallic acid, pyrogallol and vanillin were found to be 8.04, 5.21, 5.45, 3.73, 5.44, 4.85, 5.47 and 6.57 % respectively. For the investigated analytes, the correlation coefficient was found in the range of 0.9803 to 0.9981. Furthermore, antioxidant properties of the extracts were determined based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), beta-carotene linoleic acid and cupric (Cu2+) ion reducing power assay (CUPRAC). Acetone (Ac) and methanol (M2) extracts showed high activity in all test assays due to their high concentration of rosmarinic acid, caffeic acid and gallic acid in the extracts. (C) 2018 ACG Publications. All rights reserved.
dc.description.sponsorshipTürkiye Bilimsel Ve Teknolojik Araştırma Kurumu ( Tübitak )
dc.identifier10.1089/photob.2018.4510
dc.identifier.citationCarikci S., Kilic T., Ozer Z., Dirmenci T., ARABACI T., Goren A. C. , -Quantitative determination of some phenolics in Origanum laevigatum Boiss. extracts via validated LC-MS/MS method and antioxidant activity-, JOURNAL OF CHEMICAL METROLOGY, cilt.12, ss.121-127, 2018
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7158
dc.language.isoen
dc.titleQuantitative determination of some phenolics in Origanum laevigatum Boiss. extracts via validated LC-MS/MS method and antioxidant activity
dc.typeArticle
dspace.entity.typePublication
local.article.journalnamePhotobiomodulation, photomedicine, and laser surgery
local.avesis.idb2568f6d-6ba0-4c5a-be20-98f964af5df4
local.avesis.response7034
relation.isAuthorOfPublication07fcea81-8515-4cd4-86f2-047fe6b2df71
relation.isAuthorOfPublication.latestForDiscovery07fcea81-8515-4cd4-86f2-047fe6b2df71
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