Direct synthesis of tetrazine functionalities on polymer backbones

Kara, Sinem Sipahioglu
Ates, Mustafa Yasin
Deveci, Gozde
Cetinkaya, Ahmet
Kahveci, Muhammet Übeydullah
Journal Title
Journal ISSN
Volume Title
Research Projects
Organizational Units
Journal Issue

Tetrazine mediated inverse Electron Demand Diels-Alder Reaction (IEDDA) is an important modification technique due to its high selectivity and super-fast kinetics. Incorporation of tetrazine moieties on polymer chains requires multistep synthetic pathways and a post-polymerization step leading to functional polymeric materials. Such approaches involve separate syntheses of polymer and the molecule which will be employed in modification. Herein, we introduce a straightforward synthetic approach for direct synthesis of tetrazine groups on polymers as side chains. As model systems, tetrazine functional poly(N-isopropylacrylamide)-and poly(ethylene glycol)-based polymers from corresponding precursor polymers with nitrile moieties as pendant groups are prepared and IEDDA Click Reaction is achieved with trans-cyclooctene derivatives. The click reaction is monitored by both NMR and UV-vis spectroscopies. (c) 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 673-680

Kara S. S. , Ates M. Y. , Deveci G., Cetinkaya A., Kahveci M. Ü. , -Direct synthesis of tetrazine functionalities on polymer backbones-, JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, cilt.57, ss.673-680, 2019
Sustainable Development Goals