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Does ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury

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dc.contributor.authorAydogdu, Ibrahim
dc.contributor.authorIlbey, YUSUF ÖZLEM
dc.contributor.authorÇOBAN, GANİME
dc.contributor.authorEkin, Rahmi Gokhan
dc.contributor.authorMirapoglu, Semih Lutfi
dc.contributor.authorCay, Ali
dc.contributor.authorKiziltan, Huriye Senay
dc.contributor.authorEkin, Zubeyde Yildirim
dc.contributor.authorSilay, Mesrur Selcuk
dc.contributor.authorSEMERCİ, MEHMET BÜLENT
dc.contributor.institutionauthorAYDOĞDU, İBRAHİM
dc.contributor.institutionauthorİLBEY, YUSUF ÖZLEM
dc.contributor.institutionauthorÇOBAN, GANİME
dc.contributor.institutionauthorMİRAPOĞLU, SEMİH LÜTFİ
dc.contributor.institutionauthorÇAY, ALI
dc.contributor.institutionauthorKIZILTAN, HURİYE ŞENAY
dc.date.accessioned2022-01-27T20:59:49Z
dc.date.available2022-01-27T20:59:49Z
dc.date.issued2019-03-01T00:00:00Z
dc.description.abstractObjective: We investigate the protective and therapeutic effects of ozone therapy (OT) in radiotherapy (RT)-induced testicular damage. Methods: Thirty healthy adult male Wistar rats divided into five groups consisting of six animals each as follows: (1) Control (C), (2) RT, (3) OT, (4) OT + RT, and (5) RT + OT group. Histopathological findings, Johnsen scores, thiobarbituric acid-reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) levels were evaluated. Results: RT caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS level was significantly higher, whereas GSH, SOD, catalase, and GPx levels were significantly lower in the RT group when compared to the control group. Pre and postRT OT significantly increased GSH, SOD, catalase, and GPx levels and decreased TBARS level. Furthermore, testicular weight and Johnsen score were increased with OT. Conclusions: The present study showed that OT is protective and therapeutic in radiation-induced testicular damage. OT may be beneficial to the patients who underwent RT.
dc.identifier.citationAydogdu I., Ilbey Y. Ö. , ÇOBAN G., Ekin R. G. , Mirapoglu S. L. , Cay A., Kiziltan H. S. , Ekin Z. Y. , Silay M. S. , SEMERCİ M. B. , -Does ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury-, JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, cilt.15, 2019
dc.identifier.doi10.4103/jcrt.jcrt_322_17
dc.identifier.pubmed30900625
dc.identifier.scopus85063491096
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30315
dc.identifier.wosWOS:000462681000013
dc.titleDoes ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury
dc.typeArticle
dspace.entity.typePublication
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local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery92813154-621b-468c-8399-8510ae43f718
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