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Studies on the cytotoxic, apoptotic and antitumoral effects of Au(III) and Pt(II) complexes of 1, 10-phenanthroline on V79 379A and A549 cell lines

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dc.contributor.authorBostancioglu, R. Beklem
dc.contributor.authorIsik, Kenan
dc.contributor.authorGenc, Hatice
dc.contributor.authorBenkli, Kadriye
dc.contributor.authorKoparal, Ayse Tansu
dc.date.accessioned2020-10-29T23:12:52Z
dc.date.available2020-10-29T23:12:52Z
dc.date.issued2012-06-01T00:00:00Z
dc.description.abstractIn the present study, Au(III) and Pt(II) complexes of 1, 10-phenanthroline (phen) were synthesized and used as the test compounds. The structure elucidation of the synthesized compounds was performed by IR, H-1-NMR and MASS spectroscopic data and the results of elemental analyses. The cytotoxic and apoptotic effects of test compounds were elucidated on V79 379A (Chinese hamster lung fibroblast like) and A549 (human lung carcinoma epithelial like) cell lines. Cytotoxicity was measured with MTT assay and antitumoral effect was determined by colony forming ability methods. In addition, nuclear fragmentation and activation of apoptotic enzyme (caspase-3) and DAPI staining were used to detect the apoptotic effect of the compounds. All the test compounds induced time and concentration-dependent cytotoxic and antitumoral effects. Significant increases in the levels of apoptosis were observed with increasing exposure concentration.
dc.identifier.citationBostancioglu R. B. , Isik K., Genc H., Benkli K., Koparal A. T. , -Studies on the cytotoxic, apoptotic and antitumoral effects of Au(III) and Pt(II) complexes of 1, 10-phenanthroline on V79 379A and A549 cell lines-, JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.27, ss.458-466, 2012
dc.identifier.doi10.3109/14756366.2011.596835
dc.identifier.scopus84860384775
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26943
dc.identifier.wosWOS:000303330100018
dc.titleStudies on the cytotoxic, apoptotic and antitumoral effects of Au(III) and Pt(II) complexes of 1, 10-phenanthroline on V79 379A and A549 cell lines
dc.typeArticle
dspace.entity.typePublication
local.avesis.idd5fdc372-2a09-453c-975b-a8d392310ccb
local.publication.isinternational1
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