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Glucose levels show independent and dose-dependent association with worsening acute pancreatitis outcomes: Post-hoc analysis of a prospective, international cohort of 2250 acute pancreatitis cases.

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dc.contributor.authorPecsi, Daniel
dc.contributor.authorIlles, Dora
dc.contributor.authorVancsa, Szilard
dc.contributor.authorFöldi, Maria
dc.contributor.authorIzbéki, Ferenc
dc.contributor.authorNagy, Tamas
dc.contributor.authorKanizsai, Peter
dc.contributor.authorMarton, Zsolt
dc.contributor.authorHegyi, Peter
dc.contributor.authorParniczky, Andrea
dc.contributor.authorNagy, Anyko
dc.contributor.authorGörbe, Aniko
dc.contributor.authorTörök, Imola
dc.contributor.authorStimac, Davor
dc.contributor.authorVincze, Aron
dc.contributor.authorSarlos, Patrícia
dc.contributor.authorCzimmer, Jozsef
dc.contributor.authorSzepes, Zoltan
dc.contributor.authorTakacs, Tamas
dc.contributor.authorPapp, Maria
dc.contributor.authorFeher, Eszter
dc.contributor.authorHamvas, Jozsef
dc.contributor.authorKaraasz, Klaudia
dc.contributor.authorFarkas, Orsolya
dc.contributor.authorİnce, Ali Tüzün
dc.contributor.authorEross, Balint
dc.contributor.authorMarta, Katalin
dc.contributor.institutionauthorİNCE, ALİ TÜZÜN
dc.date.accessioned2021-07-29T20:59:07Z
dc.date.available2021-07-29T20:59:07Z
dc.date.issued2021-07-01T00:00:00Z
dc.description.abstractBackgroundMetabolic risk factors, such as obesity, hypertension, andhyperlipidemiaare independent risk factors for the development of various complications in acute pancreatitis (AP).Hypertriglyceridemiadose-dependently elicits pancreatotoxicity and worsens the outcomes of AP. The role ofhyperglycemia, as a toxic metabolic factor in the clinical course of AP, has not been examined yet.MethodsWe analyzed a prospective, international cohort of 2250 AP patients, examining associations between (1)glycosylated hemoglobin(HbA1c), (2) on-admission glucose, (3) peak in-hospital glucose and clinically important outcomes (mortality, severity, complications, length of hospitalization (LOH), maximal C-reactive protein (CRP)). We conducted a binarylogistic regressionaccounting for age, gender, etiology, diabetes, and our examined variables. Receiver Operating Characteristic Curve (ROC) was applied to detect the diagnostic accuracy of the three variables.ResultsBoth on-admission and peak serum glucose are independently associated with AP severity and mortality, accounting for age, gender, known diabetes and AP etiology. They show a dose-dependent association with severity (p<0.001 in both), mortality (p<0.001), LOH (p<0.001), maximal CRP (p<0.001), systemic (p<0.001) and local complications (p<0.001). Patients with peak glucose >7mmol/l had a 15 times higher odds for severe AP and a five times higher odds for mortality. We found a trend of increasingHbA1cwith increasing LOH (p<0.001), severity and local complications.ConclusionsOn-admission and peak in-hospital glucose are independently and dose-dependently associated with increasing AP severity and mortality. In-hospital laboratory control of glucose and adequate treatment of hyperglycemia are crucial in themanagement of AP.KeywordsGlucoseHemoglobin A1cDose-dependencyPancreatotoxicityAcute pancreatitis
dc.identifier.citationNagy A., Juhász M. F. , Görbe A., Varadi A., Izbéki F., Vincze A., Sarlos P., Czimmer J., Szepes Z., Takacs T., et al., -Glucose levels show independent and dose-dependent association with worsening acute pancreatitis outcomes: Post-hoc analysis of a prospective, international cohort of 2250 acute pancreatitis cases.-, Pancreatology, cilt.22, sa.1, ss.1-10, 2021
dc.identifier.doi10.1016/j.pan.2021.06.003
dc.identifier.pubmed34332908
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29098
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleGlucose levels show independent and dose-dependent association with worsening acute pancreatitis outcomes: Post-hoc analysis of a prospective, international cohort of 2250 acute pancreatitis cases.
dc.typeArticle
dspace.entity.typePublication
local.avesis.idfa09b6d3-4b9c-467d-8f63-15510035f79a
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery6daa6ab7-ee45-4f50-9e71-e831046b6462
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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