Comparison of Inflammatory Markers and in Hospital Clinical Course In Patients with Lead versus Non-lead Left Sided Endocarditis

Abstract

Objectıves We aimed to compare inflammatory markers and in hospital clinical course in patients with lead versus non-lead left sided endocarditis which has not been reported previously.

Methods One hundred seventy three consecutive infective endocartidis patients with a mean age of 48,5 ± 18,2 (range between 10-89; 99 male, 74 female) were included into the study. Patients were divided into two groups according to endocarditis type (group 1, lead endocarditis, n=17 and group 2, non-lead left sided endocarditis, n=156). Red cell distribution width (RDW), neutrophile-lymphocyte ratio (NLR) and peak high sensitive C-reactive protein (hs-CRP) levels were measured. We also evaluated in hospital clinical course of the patients.

Results RDW, NLR and peak hs-CRP levels were significantly lower in patients with lead endocarditis when compared with non-lead endocarditis (14,8 ± 1,6 versus 16,7 ± 3,1, p=0,01, 2,9 ± 1,07 versus 7,4 ± 7, p=0,01 and 22,4 ± 31,3 versus 58,6 ± 69, p=0,03 respectively). In hospital mortality was similar in two groups (11.7% versus 30.1%, p=0.11). Ejection fraction was lower in the group with lead endocarditis (49,7% ± 14,4 versus 55,6% ± 9.8, p=0.03) however, clinical congestive heart failure was more common in the non-lead endocarditis group (28,2% versus 5,8%, p=0.004).

Conclusıon In hospital mortality was similar in patients with lead and non-lead left sided endocarditis. Inflammatory markers such as RDW, NLR and hs-CRP were lower in lead endocarditis. Additionally despite of lower ejection, clinical congestive heart failure development was less in lead endocarditis which all should alert physicians that lead endocarditis might have more silent course and might be omitted.