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The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: A study of 53 cases

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dc.contributor.authorKiran, Tuğçe
dc.contributor.authorDemirkesen, Cuyan
dc.contributor.authorEker, Candan
dc.contributor.authorKumusoglu, Hakki
dc.contributor.authorTuzuner, Nukhet
dc.contributor.institutionauthorKIRAN, TUĞÇE
dc.date.accessioned2021-01-13T20:59:06Z
dc.date.available2021-01-13T20:59:06Z
dc.date.issued2013-04-01T00:00:00Z
dc.description.abstractCurrent laboratory technics, clinicopathologic findings cannot always reliably distinguish primary cutaneous CD30(+) lymphoproliferative disorders (LPD), such as lymphomatoid papulosis (LyP), primary cutaneous CD30(+) anaplastic large cell lymphoma (PCALCL), transformed mycosis fungoides (T-MF) and systemic ALK(−) anaplastic large cell lymphoma (ALCL) with skin involvement. We investigated the presence of IRF4 translocation with break apart DNA-FISH method of these entities according to the recent studies of Feldman et al. In our study group with 53 cases, the detection of IRF4 translocation had a specificity and positive predictive value for PCALCL of 100%. In contrast MUM1/IRF4 protein expression was distributed widely without any predictive value.
dc.identifier.citationKiran T., Demirkesen C., Eker C., Kumusoglu H., Tuzuner N., -The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: A study of 53 cases-, LEUKEMIA RESEARCH, cilt.37, ss.396-400, 2013
dc.identifier.doi10.1016/j.leukres.2012.12.001
dc.identifier.pubmed
dc.identifier.scopus84875381726
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27884
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0145212612004584?via%3Dihub
dc.identifier.wosWOS:000315744500009
dc.identifier.yoksis4492169
dc.subjectALCL
dc.subjectIRF4 translocation
dc.titleThe significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: A study of 53 cases
dc.typeArticle
dspace.entity.typePublication
local.avesis.id7ffdbd70-8f21-42c6-8737-c694de086ff0
local.publication.isinternational1
relation.isAuthorOfPublicationa9f1cbb0-2ed9-4cfa-a875-3bc2ed39c1a7
relation.isAuthorOfPublication.latestForDiscoverya9f1cbb0-2ed9-4cfa-a875-3bc2ed39c1a7
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