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ASSESSMENT OF URINARY 8-HYDROXYDEOXYGUANOSINE LEVEL IN DIABETIC CANCER PATIENTS

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dc.contributor.authorAl-Taie, Anmar
dc.contributor.authorIzzettin, Fikret V.
dc.contributor.authorSANCAR, MESUT
dc.contributor.authorKOSEOGLU, Aygul
dc.contributor.authorALIUSTAOGLU, Mehmet
dc.contributor.authorKAPTANAGASI, Asuman
dc.contributor.institutionauthorİZZETTİN, FIKRET VEHBI
dc.date.accessioned2020-10-29T14:37:27Z
dc.date.available2020-10-29T14:37:27Z
dc.date.issued2017-04-01T00:00:00Z
dc.description.abstractBoth diabetes mellitus and cancer are characterised by higher levels of oxidative stress and production of free radicals, which further complicate the control and outcomes of these diseases. The aim of this study was to assess the level of urinary 8-Hydroxydeoxyguanosine in diabetic cancer patients as a biomarker of cellular oxidative stress for both disease progression and chemotherapy administration. A controlled prospective observational study carried out on 100 diabetic patients newly diagnosed with diverse cancer types eligible for different chemotherapeutic protocols at the oncology unit. Urinary 8-Hydroxydeoxyguanosine level assessed at the baseline (before the required chemotherapy protocol schedule), and the 2nd reading (at the end of the required chemotherapy protocol schedule). Results showed that there was a significant (p<0.05) increase the urinary 8-Hydroxydeoxyguanosine level between the baseline and 2nd readings (27.04 +/- 4.33 ng/dl) vs (30.77 +/- 4.63ng/dl), and between the baseline and 2nd readings at 7-day course (25.96 +/- 4.21ng/dl) vs (28.16 +/- 5.27ng/dl), at 14-day course (27.76 +/- 5.33 ng/dl) vs (31.56 +/- 4.47ng/dl), and at 21-day course (27.22 +/- 4.16 ng/dl) vs (31.40 +/- 4.24ng/dl). In conclusion, this study presented that oxidative stress based on elevation of the urinary 8-OHdG level is related to diabetes mellitus and cancer which is further boosted during chemotherapy administration.
dc.identifier.citationAl-Taie A., Izzettin F. V. , SANCAR M., KOSEOGLU A., ALIUSTAOGLU M., KAPTANAGASI A., -ASSESSMENT OF URINARY 8-HYDROXYDEOXYGUANOSINE LEVEL IN DIABETIC CANCER PATIENTS-, INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, cilt.8, ss.1619-1623, 2017
dc.identifier.doi10.13040/ijpsr.0975-8232.8(4).1619-23
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25335
dc.identifier.wosWOS:000402798400014
dc.titleASSESSMENT OF URINARY 8-HYDROXYDEOXYGUANOSINE LEVEL IN DIABETIC CANCER PATIENTS
dc.typeArticle
dspace.entity.typePublication
local.avesis.id263d0ccc-248d-4eab-b303-b1e344ad08b5
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublicationcc4fb95b-daac-4065-9eea-9b57f6b44654
relation.isAuthorOfPublication.latestForDiscoverycc4fb95b-daac-4065-9eea-9b57f6b44654
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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