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The relationship of Serum Histone H3.3 and H4 with chronic Hepatitis B

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dc.contributor.authorSümbül, Bilge
dc.contributor.authorŞentürk, Hakan
dc.contributor.authorKöker, İbrahim Hakkı
dc.contributor.authorKoçhan, Koray
dc.contributor.authorİnce, Ali Tüzün
dc.contributor.authorBiberci Keskin, Elmas
dc.contributor.institutionauthorİNCE, ALİ TÜZÜN
dc.contributor.institutionauthorBİBERCİ KESKİN, ELMAS
dc.contributor.institutionauthorSÜMBÜL, BİLGE
dc.contributor.institutionauthorKOÇHAN, KORAY
dc.contributor.institutionauthorKÖKER, İBRAHİM HAKKI
dc.contributor.institutionauthorŞENTÜRK, HAKAN
dc.date.accessioned2020-08-31T20:59:22Z
dc.date.available2020-08-31T20:59:22Z
dc.date.issued2020-09-01T00:00:00Z
dc.description.abstractObjective: To determine the role of serum histone H3.3 and H4 in patients with chronic hepatitis B to explore any relationship between the two.Methods: The prospective controlled clinical pilot study was conducted in the Gastroenterology Clinic of Bezmialem Vakif University, Istanbul, Turkey, from January to October 2017, and comprised biopsy-proven patients with chronic hepatitis B and healthy controls. Demographics, hepatitis B virus deoxyribonucleic acid quantity, hepatitis B e-antigen, aspartate aminotransferase, alanine transaminase, international normalized ratio, total/direct bilirubin, albumin and thrombocyte counts as well as histological activity index and fibrosis scores were noted. Data was analysed using SPSS 22.Results: Of the 140 subjects, 70(50%) each were cases and controls. The overall mean age of the sample was 43.38±15.07 years (range: 18-70 years). There was positive correlation of histone H3.3 with hepatitis B virus deoxyribonucleic acid, aspartate aminotransferase, alanine transaminase and international normalized ratio levels. Histone H4 levels only correlated with hepatitis B virus deoxyribonucleic acid and international normalized ratio. Hepatitis B e-antigen positivity was present in 14(20%) of the cases.Conclusion: Histone H3.3 levels appeared to be associated with pathophysiological changes in chronic hepatitis B patients, suggesting that future treatments should target H3.3.Keywords: Histone H3.3, Histone H4, Extracellular histone, Chronic Hepatitis B, HBV.(JPMA 70: 1596; 2020)DOI:https://doi.org/10.5455/JPMA.19365
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier.citationİnce A. T. , Biberci Keskin E., Sümbül B., Koçhan K., Köker İ. H. , Şentürk H., -The relationship of Serum Histone H3.3 and H4 with chronic Hepatitis B-, JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, cilt.70, ss.1596-1600, 2020
dc.identifier.doi10.5455/jpma.19365
dc.identifier.pubmed33040116
dc.identifier.urihttp://hdl.handle.net/20.500.12645/18478
dc.identifier.urihttps://jpma.org.pk/article-details/10114?article_id=10114
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHistone H3.3en
dc.subjectHistone H4en
dc.subjectExtracellular histone
dc.subjectChronic Hepatitis B
dc.subjectHBV
dc.titleThe relationship of Serum Histone H3.3 and H4 with chronic Hepatitis B
dc.typeArticle
dspace.entity.typePublication
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local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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