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Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?

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dc.contributor.authorCemil, BC
dc.contributor.authorYilmazer, D
dc.contributor.authorAtas, H
dc.contributor.authorCengiz, Fatma Pelin
dc.contributor.authorCanpolat, F
dc.contributor.authorAlper, M
dc.contributor.authorGonul, M
dc.contributor.institutionauthorCENGİZ, FATMA PELIN
dc.date.accessioned2020-01-20T20:59:29Z
dc.date.available2020-01-20T20:59:29Z
dc.date.issued2017-08-01T00:00:00Z
dc.description.abstractIntroduction: Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis. Aim: To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP. Material and methods: Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group. Results: The comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls (p < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients. Conclusions: Our study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions.en
dc.identifier.citationCemil B., Yilmazer D., Atas H., Cengiz F. P. , Canpolat F., Alper M., Gonul M., -Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?-, Postepy dermatologii i alergologii, cilt.34, ss.322-327, 2017
dc.identifier.doi10.5114/ada.2017.69311
dc.identifier.pubmed28951706
dc.identifier.scopus85026644988
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/13446
dc.identifier.wosWOS:000408254400006
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleDoes the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?
dc.typeArticle
dspace.entity.typePublication
local.avesis.id838a1d2a-bdec-4568-bcbc-0183f13eb67e
local.publication.isinternational1
relation.isAuthorOfPublication292e9ebe-735f-4346-90cf-5e0d8d0ed89d
relation.isAuthorOfPublication.latestForDiscovery292e9ebe-735f-4346-90cf-5e0d8d0ed89d
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