Publication:
Serum Irisin Levels in Central Precocious Puberty and Its Variants.

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dc.contributor.authorÖzgen, İT
dc.contributor.authorKutlu, E
dc.contributor.authorBulut, H
dc.contributor.authorKoçyiğit, ABDÜRRAHİM
dc.contributor.authorOtçu, H
dc.contributor.institutionauthorÖZGEN, İLKER TOLGA
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorCESUR, YAŞAR
dc.date.accessioned2020-10-26T17:22:45Z
dc.date.available2020-10-26T17:22:45Z
dc.date.issued2020-10-09T00:00:00Z
dc.description.abstractAim: The exact mechanisms that trigger the onset of puberty are not well known. Adipomyokines are postulated to stimulate the central neural network. In the present study, we investigated irisin levels in girls with central precocious puberty (CPP), slowly progressing precocious puberty (SPPP) or premature thelarche (PT), and also prepubertal girls and determined if this adipomyokine could be used as a marker in this context. Methods: A total of 94 girls including 33 with CPP, 31 with precocious puberty (PP) variants (SPPP or PT), and 30 healthy controls were enrolled to the study. The mean irisin levels were compared between the groups. The bivariate correlations of irisin levels with clinical and laboratory parameters were assessed. Multivariate linear regression analysis was performed to determine independent predictive factors of irisin levels. Results: Irisin levels were higher in the CPP group compared with the other groups (CPP group: 723.25±62.35 ng/mL, PP variants group: 529.60±39.66 ng/mL, and control group: 325.03±27.53 ng/mL) (p<0.001). Irisin levels were positively correlated with body mass index standard deviation scores (SDS); height-SDS; weight-SDS; bone age; uterus long axis; size of the ovary; baseline follicle stimulating hormone and luteinizing hormone (LH); and peak LH levels. Multivariate linear regression analysis revealed that irisin levels had the strongest correlation with peak LH. The other independent predictive factor of irisin levels was BMI-SDS. Conclusions: The mean irisin levels were higher in patients with CPP compared with other groups. The results of this study imply that increased irisin levels may be used as a marker of CPP provided that these findings are confirmed in larger prospective studies.en
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier.citationKutlu E., Özgen İ., Bulut H., Koçyiğit A., Otçu H., Cesur Y., -Serum Irisin Levels in Central Precocious Puberty and Its Variants.-, The Journal of clinical endocrinology and metabolism, 2020
dc.identifier.doi10.1210/clinem/dgaa720
dc.identifier.pubmed33034623
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25024
dc.identifier.urihttps://doi.org/10.1210/clinem/dgaa720
dc.subjectIrisin
dc.subjectPrecocious pubertyen
dc.subjectAdipomyokineen
dc.subjectPremature thelarcheen
dc.subjectSlowly progressing precocious pubertyen
dc.titleSerum Irisin Levels in Central Precocious Puberty and Its Variants.
dc.typeArticle
dspace.entity.typePublication
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local.publication.isinternational1
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