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Omentin-1 level in adolescents with polycystic ovarian syndrome.

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dc.contributor.authorÖzgen, İT
dc.contributor.authorCesur, Y
dc.contributor.authorOruçlu, Ş
dc.contributor.authorSelek, ŞAHBETTİN
dc.contributor.authorKutlu, E
dc.contributor.authorGuzel, G
dc.contributor.institutionauthorÖZGEN, İLKER TOLGA
dc.contributor.institutionauthorSELEK, ŞAHABETTİN
dc.contributor.institutionauthorCESUR, YAŞAR
dc.date.accessioned2019-10-05T14:56:25Z
dc.date.available2019-10-05T14:56:25Z
dc.date.issued2019-02-01
dc.description.abstractBackground Adipokines have been suggested to play an important role in the pathogenesis of polycystic ovarian syndrome (PCOS). Omentin is an adipokine secreted essentially by visceral adipose tissue with an insulin-sensitizing effect. Insulin resistance (IR) is a common feature of PCOS, therefore the aim of this study was to investigate omentin-1 level in adolescent girls with PCOS and its relationship with IR and androgens. Method A total of 41 obese girls with PCOS, and 30 age- and body mass index (BMI)-matched obese girls without PCOS were enrolled in the study. The demographic, clinic and laboratory characteristics of the groups were compared. Additionally, bivariate correlation analysis of omentin-1 with BMI standard deviation score (BMI-SDS), insulin, glucose, homeostatic model assessment of IR (HOMA-IR), total and free testosterone was performed. Results In the PCOS group HOMA-IR, free and total testosterone were higher than in the control group. Omentin-1 was lower in the PCOS group compared with the controls (55.01 +/- 7.99 ng/mL vs 59.10 +/- 7.02 ng/mL, respectively; P = 0.027). Omentin-1 was inversely correlated with free testosterone (r = -0.527, P = 0.030) and BMI-SDS (r = -0.241, P = 0.046) but it was not correlated with total testosterone, HOMA-IR, glucose, insulin or serum lipids. Conclusion Omentin-1 was lower in obese girls with PCOS and hyperandrogenism was associated with this condition.
dc.identifier
dc.identifier.citationÖzgen İ., Oruçlu Ş., Selek Ş., Kutlu E., Guzel G., Cesur Y., -Omentin-1 level in adolescents with polycystic ovarian syndrome.-, Pediatrics international : official journal of the Japan Pediatric Society, cilt.61, ss.147-151, 2019
dc.identifier.doi10.1111/ped.13761
dc.identifier.pubmed30566253
dc.identifier.scopus85062056349
dc.identifier.urihttps://hdl.handle.net/20.500.12645/5120
dc.identifier.wosWOS:000459796600004
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleOmentin-1 level in adolescents with polycystic ovarian syndrome.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameVIRCHOWS ARCHIV
local.avesis.id7e18acd4-f17c-42f8-be64-08fd76fe9113
local.avesis.response4990
local.publication.isinternational1
relation.isAuthorOfPublicationc6ad9225-905e-4761-8da0-36efba996f82
relation.isAuthorOfPublication8eb7d539-8ea4-435c-830e-8ef630342c7d
relation.isAuthorOfPublicationddd881a5-c7cb-41e5-b4e1-0693a98a0d29
relation.isAuthorOfPublication.latestForDiscovery8eb7d539-8ea4-435c-830e-8ef630342c7d
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