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STATdb: A Specialised Resource for the STATome

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dc.contributor.authorPatro, C. Pawan K.
dc.contributor.authorKhan, Asif M.
dc.contributor.authorTan, Tin Wee
dc.contributor.authorFu, Xin-Yuan
dc.contributor.institutionauthorKHAN, MOHAMMAD ASİF
dc.date.accessioned2021-08-31T20:59:20Z
dc.date.available2021-08-31T20:59:20Z
dc.date.issued2014-08-01T00:00:00Z
dc.description.abstractSignal transducers and activators of transcription (STAT) proteins are key signalling molecules in metazoans, implicated in various cellular processes. Increased research in the field has resulted in the accumulation of STAT sequence and structure data, which are scattered across various public databases, missing extensive functional annotations, and prone to effort redundancy because of the dearth of community sharing. Therefore, there is a need to integrate the existing sequence, structure and functional data into a central repository, one that is enriched with annotations and provides a platform for community contributions. Herein, we present STATdb (publicly available at http://statdb.bic.nus.edu.sg/), the first integrated resource for STAT sequences comprising 1540 records representing the known STATome, enriched with existing structural and functional information from various databases and literature and including manual annotations. STATdb provides advanced features for data visualization, analysis and prediction, and community contributions. A key feature is a meta-predictor to characterise STAT sequences based on a novel classification that integrates STAT domain architecture, lineage and function. A curation policy workflow has been devised for regulated and structured community contributions, with an update policy for the seamless integration of new data and annotations.
dc.identifier.citationPatro C. P. K. , Khan A. M. , Tan T. W. , Fu X., -STATdb: A Specialised Resource for the STATome-, PLOS ONE, cilt.9, sa.8, 2014
dc.identifier.doi10.1371/journal.pone.0104597
dc.identifier.scopus84929290087
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29314
dc.identifier.wosWOS:000341303200014
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleSTATdb: A Specialised Resource for the STATome
dc.typeArticle
dspace.entity.typePublication
local.avesis.id6be656c8-becd-4ff7-9e51-6d61ae8d4e79
local.publication.isinternational1
relation.isAuthorOfPublication60fee672-8864-4711-ae92-5b9dd3bb0ef7
relation.isAuthorOfPublication.latestForDiscovery60fee672-8864-4711-ae92-5b9dd3bb0ef7
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