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Isolation and Characterization of Werneria Chromene and Dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle

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dc.contributor.authorZulkipli, Masyitah
dc.contributor.authorMahbub, Nuzum
dc.contributor.authorFATIMA, AYESHA
dc.contributor.authorWan-Lin, Stefanie Lim
dc.contributor.authorKhoo, Teng-Jin
dc.contributor.authorMahboob, Tooba
dc.contributor.authorRajagopal, Mogana
dc.contributor.authorSamudi, Chandramathi
dc.contributor.authorKathirvalu, Gheetanjali
dc.contributor.authorAbdullah, Nor Hayati
dc.contributor.authorPinho, Ana Rita
dc.contributor.authorOliveira, Sonia M. R.
dc.contributor.authorPereira, Maria de Lourdes
dc.contributor.authorRahmatullah, Mohammed
dc.contributor.authorHasan, Anamul
dc.contributor.authorPaul, Alok K.
dc.contributor.authorButler, Mark S.
dc.contributor.authorNawaz, Muhammad
dc.contributor.authorWilairatana, Polrat
dc.contributor.authorNissapatorn, Veeranoot
dc.contributor.authorWiart, Christophe
dc.contributor.institutionauthorFATIMA, AYESHA
dc.date.accessioned2022-06-21T20:59:13Z
dc.date.available2022-06-21T20:59:13Z
dc.date.issued2022-06-01T00:00:00Z
dc.description.abstractThe secondary metabolites of endemic plants from the Rutaceae family, such as Burkillanthus malaccensis (Ridl.) Swingle from the rainforest of Malaysia, has not been studied. Burkillanthus malaccensis (Ridl.) Swingle may produce antibacterial and antibiotic-potentiating secondary metabolites. Hexane, chloroform, and methanol extracts of leaves, bark, wood, pericarps, and endocarps were tested against bacteria by broth microdilution assay and their antibiotic-potentiating activities. Chromatographic separations of hexane extracts of seeds were conducted to investigate effective phytochemicals and their antibacterial activities. Molecular docking studies of werneria chromene and dihydroxyacidissiminol against SARS-CoV-2 virus infection were conducted using AutoDock Vina. The methanol extract of bark inhibited the growth of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa with the minimum inhibitory concentration of 250, 500, and 250 mu g/mL, respectively. The chloroform extract of endocarps potentiated the activity of imipenem against imipenem-resistant Acinetobacter baumannii. The hexane extract of seeds increased the sensitivity of P. aeruginosa against ciprofloxacin and levofloxacin. The hexane extract of seeds and chloroform extract of endocarps were chromatographed, yielding werneria chromene and dihydroxyacidissiminol. Werneria chromene was bacteriostatic for P. aeruginosa and P. putida, with MIC/MBC values of 1000 > 1000 mu g/mL. Dihydroxyacidissiminol showed the predicted binding energies of -8.1, -7.6, -7.0, and -7.5 kcal/mol with cathepsin L, nsp13 helicase, SARS-CoV-2 main protease, and SARS-CoV-2 spike protein receptor-binding domain S-RBD. Burkillanthus malaccensis (Ridl.) Swingle can be a potential source of natural products with antibiotic-potentiating activity and that are anti-SARS-CoV-2.
dc.identifier.doi10.3390/plants11111388
dc.identifier.pubmed35684161
dc.identifier.scopus85130795065
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30760
dc.identifier.wosWOS:000808723300001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBurkillanthus malaccensis
dc.subjectSARS-CoV-2
dc.subjectantibiotic potentiator
dc.subjectcathepsin L
dc.subjectdihydroxyacidissiminol
dc.subjectnsp13 helicase
dc.subjectspike protein
dc.subjectwerneria chromene
dc.titleIsolation and Characterization of Werneria Chromene and Dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle
dc.typeArticle
dspace.entity.typePublication
local.avesis.id186c33f4-7631-44d9-97ff-181039701b85
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication42c43eb9-9434-445b-a4b1-9aedfd0731a6
relation.isAuthorOfPublication.latestForDiscovery42c43eb9-9434-445b-a4b1-9aedfd0731a6
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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