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Beta-glucan attenuates cerebral ischemia/reperfusion-induced neuronal injury in a C57BL/J6 mouse model

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dc.contributor.authorKAYA, KÜRŞAT
dc.contributor.authorÇİFTÇİ, OSMAN
dc.contributor.authorÖZTANIR, MUSTAFA NAMIK
dc.contributor.authorTAŞLIDERE, ELİF
dc.contributor.authorBAŞAK TÜRKMEN, NEŞE
dc.contributor.institutionauthorTAŞLIDERE, ELİF
dc.date.accessioned2020-10-22T20:22:58Z
dc.date.available2020-10-22T20:22:58Z
dc.date.issued2019-01-01T00:00:00Z
dc.description.abstractBeta-glucans (beta g), that have many useful effects on human health, are natural polysaccharides. Our aim in this study was to determine useful effect of beta g against oxidative and neuronal damage caused by global cerebral ischemia/reperfusion (IR) in stroke imitated mice via surgical operation. A total of 40 mice divided into four equal groups randomly. The group 1 (sham operated) was kept as control. Bilateral carotid arteries of subjects in group 2 (I/R) and group 4 (I/R + beta g) were clipped for 15 min, and the mice in group 4 (I/R + beta g) were treated with beta g (50 mg/kg/day), while the mice in group 2 (I/R) were treated with only vehicle for 10 days. The mice of group 3 (beta g) were treated with beta g for 10 days without carotid occlusion. Global cerebral I/R significantly increased oxidative stress and decreased members of anti-oxidant defense system. In addition, I/R caused histopathological damage in the brain tissue. However, beta g treatment ameliorated both oxidative and histopathological effects of I/R. Our present study showed that beta g treatment significantly ameliorated oxidative and histological damage in the brain tissue caused by cerebral I/R. Therefore, beta g treatment can be used as supportive care for ischemic stroke patients.
dc.identifier.citationKAYA K., ÇİFTÇİ O., ÖZTANIR M. N. , TAŞLIDERE E., BAŞAK TÜRKMEN N., -Beta-glucan attenuates cerebral ischemia/reperfusion-induced neuronal injury in a C57BL/J6 mouse model-, BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.55, 2019
dc.identifier.doi10.1590/s2175-97902019000218312
dc.identifier.scopus85074269923
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24740
dc.identifier.wosWOS:000494326400001
dc.titleBeta-glucan attenuates cerebral ischemia/reperfusion-induced neuronal injury in a C57BL/J6 mouse model
dc.typeArticle
dspace.entity.typePublication
local.avesis.ide21e1a66-02d0-4ff8-9b65-9d4b5aede867
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication1bcd2ccf-c1aa-4999-a863-1d634b1c7fe6
relation.isAuthorOfPublication.latestForDiscovery1bcd2ccf-c1aa-4999-a863-1d634b1c7fe6
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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