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Assessment of the antiproliferative and apoptotic roles of sulfonamide carbonic anhydrase IX inhibitors in HeLa cancer cell line

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dc.contributor.authorKoyuncu, Ismail
dc.contributor.authorGonel, Ataman
dc.contributor.authorDurgun, Mustafa
dc.contributor.authorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.authorYuksekdag, Ozgur
dc.contributor.authorSupuran, Claudiu T.
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.date.accessioned2020-01-20T20:59:28Z
dc.date.available2020-01-20T20:59:28Z
dc.date.issued2019-01-01T00:00:00Z
dc.description.abstractCarbonic anhydrase IX (CA IX) has recently been validated as an antitumor/antimetastatic drug target. In this study, we examined the underlying molecular mechanisms and the anticancer activity of sulfonamide CA IX inhibitors against cervical cancer cell lines. The effects of several sulfonamides on HeLa, MDA-MB231, HT-29 cancer cell lines, and normal cell lines (HEK-293, PNT-1A) viability were determined. The compounds showed high cytotoxic and apoptotic activities, mainly against HeLa cells overexpressing CA IX. We were also examined for intracellular reactive oxygen species (ROS) production; intra-/extracellular pH changes, for inhibition of cell proliferation, cellular mitochondrial membrane potential change and for the detection of caspase 3, 8, 9, and CA IX protein levels. Of the investigated sulfonamides, one compound was found to possess high cytotoxic and anti-proliferative effects in HeLa cells. The cytotoxic effect occurred via apoptosis, being accompanied by a return of pHe/pHi towards normal values as for other CA IX inhibitors investigated earlier.en
dc.description.sponsorshipTürkiye Bilimsel Ve Teknolojik Araştırma Kurumu ( Tübitak )
dc.identifier.citationKoyuncu I., Gonel A., Durgun M., KOÇYİĞİT A., Yuksekdag O., Supuran C. T. , -Assessment of the antiproliferative and apoptotic roles of sulfonamide carbonic anhydrase IX inhibitors in HeLa cancer cell line-, Journal of Enzyme Inhibition and Medicinal Chemistry, cilt.34, ss.75-86, 2019
dc.identifier.doi10.1080/14756366.2018.1524380
dc.identifier.pubmed30362386
dc.identifier.scopus85055414021
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/13444
dc.identifier.wosWOS:000448442900001
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleAssessment of the antiproliferative and apoptotic roles of sulfonamide carbonic anhydrase IX inhibitors in HeLa cancer cell line
dc.typeArticle
dspace.entity.typePublication
local.avesis.id74bc4795-a043-4e6e-826f-654fc0c39098
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication75babbd2-f46b-4121-aa00-54d883a6f907
relation.isAuthorOfPublication.latestForDiscovery75babbd2-f46b-4121-aa00-54d883a6f907
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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