Publication: Longitudinal analysis of treatment-induced genomic alterations in gliomas
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Henegariu, Octavian
Omay, S. Bulent
Harmanci, Akdes Serin
Youngblood, Mark W.
Mishra-Gorur, Ketu
Li, Jie
ÖZDUMAN, Koray
Carrion-Grant, Geneive
Clark, Victoria E.
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Background: Glioblastoma multiforme (GBM) constitutes nearly half of all malignant brain tumors and has a median survival of 15 months. The standard treatment for these lesions includes maximal resection, radiotherapy, and chemotherapy; however, individual tumors display immense variability in their response to these approaches. Genomic techniques such as whole-exome sequencing (WES) provide an opportunity to understand the molecular basis of this variability.
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Erson-Omay E. Z. , Henegariu O., Omay S. B. , Harmanci A. S. , Youngblood M. W. , Mishra-Gorur K., Li J., ÖZDUMAN K., Carrion-Grant G., Clark V. E. , et al., -Longitudinal analysis of treatment-induced genomic alterations in gliomas-, GENOME MEDICINE, cilt.9, 2017