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DIFFERENTIAL EXPRESSION OF BDNF, MIR-206 AND MIR-9 UNDER THE CHRONIC ETHANOL EXPOSURE AND ITS WITHDRAWAL

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dc.contributor.authorAydin Sinirlioglu, Zeynep
dc.contributor.authorAKBAŞ, FAHRİ
dc.contributor.institutionauthorAKBAŞ, FAHRİ
dc.date.accessioned2019-10-05T14:43:52Z
dc.date.available2019-10-05T14:43:52Z
dc.date.issued2016-01-01
dc.description.abstractChronic and acute alcohol abuse results in alters in the expression of some miRNAs and their mRNA targets in specific area of the brain. These expression changes might cause the cellular adjusments to long term alcohol abuse. We searched BDNF, miR-9 and miR-206 expression changed in SH SY5Y cell following exposure to ethanol and withdrawal. These miRNAs and BDNF are estimated to target genes of alcoholism. Chronic ethanol exposure and its removal showed that specific changes in miRNA and BDNF expression in cell line advocating that different expressions could be evoked with different exposure conditions. Especially, there were three group in our experiment one of them 10 days Chronic ethanol exposure, other one 5 days chronic ethanol exposure then 5 days normal medium without ethanol for withdrawal period and other group was control. After all, mir-9 was up-regulated after ethanol treatment but was downregulated in withdrawal condition. In addition mir-206 was up-regulated all condition. Whereas BDNF gene expression was regulated opposite direction according to miRNA expression. Our results suggest that a possible role of differentially expressed miRNAs and BDNF perform together in mediating alcohol influence.
dc.identifier
dc.identifier.citationAydin Sinirlioglu Z., AKBAŞ F., -DIFFERENTIAL EXPRESSION OF BDNF, MIR-206 AND MIR-9 UNDER THE CHRONIC ETHANOL EXPOSURE AND ITS WITHDRAWAL-, SIGMA JOURNAL OF ENGINEERING AND NATURAL SCIENCES-SIGMA MUHENDISLIK VE FEN BILIMLERI DERGISI, cilt.34, ss.191-196, 2016
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4597
dc.identifier.wosWOS:000379848700006
dc.language.isoen
dc.titleDIFFERENTIAL EXPRESSION OF BDNF, MIR-206 AND MIR-9 UNDER THE CHRONIC ETHANOL EXPOSURE AND ITS WITHDRAWAL
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameThe Turkish journal of pediatrics
local.avesis.id709d79d1-0a0b-442f-9542-d7f43d54d4fb
local.avesis.response4467
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication1da13c4a-283a-47d4-a763-1c242fde6919
relation.isAuthorOfPublication.latestForDiscovery1da13c4a-283a-47d4-a763-1c242fde6919
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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