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Reference intervals for growth arrest-specific 6 protein in adults

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dc.contributor.authorCagman, Zeynep
dc.contributor.authorOzakpinar, Ozlem Bingol
dc.contributor.authorCirakli, Zeynep
dc.contributor.authorGedikbasi, Asuman
dc.contributor.authorAy, Pinar
dc.contributor.authorColantonio, David
dc.contributor.authorUras, Ahmet Riza
dc.contributor.authorAdeli, Khosrow
dc.contributor.authorUras, Fikriye
dc.contributor.institutionauthorÇAĞMAN, ZEYNEP
dc.date.accessioned2020-10-22T15:54:06Z
dc.date.available2020-10-22T15:54:06Z
dc.date.issued2017-01-01T00:00:00Z
dc.description.abstractThe objective of this study was to establish reference intervals for growth arrest-specific 6 (GAS6), a vitamin K-dependent protein, in human adult plasma according to the Guideline of Clinical and Laboratory Standards Institute (CLSI) C28-A3. Blood samples were collected from 308 healthy volunteers aged 18-72 (157 female, 151 male). A non-parametric approach was used to calculate the reference interval. The plasma GAS6 reference interval was determined, with 90% confidence interval: the lower limit (2.5 percentile) was 2.5 (1.9-3.1) g/L and the upper limit (97.5 percentile)=18.8 (18.0-22.3) g/L. Harris-Boyd-s test did not suggest partitioning by age or gender: medians for males [7.8 (5.8-10.7) g/L] and females [9.9 (7.1-13.5) g/L]. Three age-subgroups were tested: 18-29 years (n=168); 30-44 years (n=73); 45-72 years (n=67). The intra- and inter-assay variations were 12.6% (mean, 5.2 +/- 0.7g/L) and 14.0% (mean, 9.2 +/- 1.3g/L), respectively. The mean recovery was 104%. This study reports plasma GAS6 reference intervals established first according to the guideline of CLSI C28-A3.
dc.identifier.citationCagman Z., Ozakpinar O. B. , Cirakli Z., Gedikbasi A., Ay P., Colantonio D., Uras A. R. , Adeli K., Uras F., -Reference intervals for growth arrest-specific 6 protein in adults-, SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, cilt.77, ss.109-114, 2017
dc.identifier.doi10.1080/00365513.2016.1275768
dc.identifier.scopus85011630039
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23604
dc.identifier.wosWOS:000395146100006
dc.titleReference intervals for growth arrest-specific 6 protein in adults
dc.typeArticle
dspace.entity.typePublication
local.avesis.id45320326-be6c-4354-890a-a4fe94f21a7d
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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