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The prognostic value of fragmented QRS in patients undergoing transcatheter aortic valve implantation

dc.contributor.authorAy, Nuray Kahraman
dc.contributor.authorENHOŞ, ASİM
dc.contributor.authorAY, YASİN
dc.contributor.authorOzdemir, Razaman
dc.contributor.authorNADİR, AYDIN
dc.contributor.authorKARAÇÖP, ERDEM
dc.contributor.authorÇELİKKALE, İLKE
dc.contributor.authorULUGANYAN, MAHMUT
dc.contributor.authorGoktekin, Omer
dc.contributor.institutionauthorKAHRAMAN AY, NURAY
dc.contributor.institutionauthorENHOŞ, ASIM
dc.contributor.institutionauthorAY, YASİN
dc.contributor.institutionauthorBAKHSALIYEV, NIJAD
dc.contributor.institutionauthorNADİR, AYDIN
dc.contributor.institutionauthorKARAÇÖP, ERDEM
dc.contributor.institutionauthorÇELİKKALE, İLKE
dc.contributor.institutionauthorULUGANYAN, MAHMUT
dc.contributor.institutionauthorÖZDEMİR, RAMAZAN
dc.date.accessioned2019-12-23T20:59:10Z
dc.date.available2019-12-23T20:59:10Z
dc.date.issued2018-11-01
dc.description.abstractBackground Although transcatheter aortic valve implantation (TAVI) can successfully correct aortic narrowing, pre-existing pathophysiological alterations in the left ventricle are still a concern in terms of long-term mortality. This study aimed to examine the predictive role of fQRS morphology on long-term prognosis in patients undergoing TAVI due to severe aortic stenosis. Methods A total of 117 patients undergoing TAVI due to severe aortic stenosis were included in this retrospective cohort study. Patients were assigned into two groups based on the presence (n = 36) or absence (n = 81) of fQRS. Predictors of long-term survival were estimated. Results In-hospital mortality was higher in fQRS group (5.5% vs. 1.2%, p = 0.0224). In the long-term, fQRS (OR: 3.06, 95% CI 1.29–7.27, p: 0.01), LVEF <50% (OR: 2.54, 95% CI 1.07–6.02, p: 0.03) and presence of atrial fibrillation (OR: 2.42, 95% CI 1.05–5.60, p: 0.03) emerged as significant independent predictors of short survival. Conclusion Presence of fQRS on ECG, an indirect indicator of myocardial fibrosis, seems to have the potential to be used as a prognostic marker after TAVI procedure. Large prospective studies are warranted.
dc.identifier.citationAy N. K. , ENHOŞ A., AY Y., Bakhshaliyev N., NADİR A., KARAÇÖP E., ÇELİKKALE İ., ULUGANYAN M., Ozdemir R., Goktekin O., -The prognostic value of fragmented QRS in patients undergoing transcatheter aortic valve implantation-, JOURNAL OF ELECTROCARDIOLOGY, cilt.51, ss.923-927, 2018
dc.identifier.pubmed30497748
dc.identifier.urihttps://hdl.handle.net/20.500.12645/10722
dc.identifier.urihttps://doi.org/10.1016/j.jelectrocard.2018.07.015
dc.subjectTranscatheter aortic valve implantation (TAVI)
dc.subjectAortic stenosis
dc.subjectFragmented QRS (fQRS)
dc.subjectMyocardial fibrosis
dc.subjectPrognosis
dc.titleThe prognostic value of fragmented QRS in patients undergoing transcatheter aortic valve implantation
dc.typeArticle
dcterms.abstractBackground:Although transcatheter aortic valve implantation (TAVI) can successfully correct aortic narrowing,pre-existing pathophysiological alterations in the left ventricle are still a concern in terms of long-term mortality.This study aimed to examine the predictive role of fQRS morphology on long-term prognosis in patients under-going TAVI due to severe aortic stenosis.Methods:A total of 117 patients undergoing TAVI due to severe aortic stenosis were included in this retrospectivecohort study. Patients were assigned into two groups based on the presence (n = 36) or absence (n = 81) offQRS. Predictors of long-term survival were estimated.Results:In-hospital mortality was higher in fQRS group (5.5% vs. 1.2%, p = 0.0224). In the long-term, fQRS(OR: 3.06, 95% CI 1.29–7.27, p: 0.01), LVEFb50% (OR: 2.54, 95% CI 1.07–6.02, p: 0.03) and presence of atrialfibril-lation (OR: 2.42, 95% CI 1.05–5.60, p: 0.03) emerged as significant independent predictors of short survival.Conclusion:Presence of fQRSon ECG, anindirect indicator of myocardialfibrosis, seemsto have the potential to beused as a prognostic marker after TAVI procedure. Large prospective studies are warranted.en
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