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Usefulness of oxidative stress marker evaluation at admission to the intensive care unit in patients with COVID-19

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dc.contributor.authorDaşkaya, Hayrettin
dc.contributor.authorYılmaz, Sinan
dc.contributor.authorUysal, Harun
dc.contributor.authorSümbül, Bilge
dc.contributor.authorKaraaslan, Kazım
dc.contributor.institutionauthorDAŞKAYA, HAYRETTİN
dc.contributor.institutionauthorYILMAZ, SİNAN
dc.contributor.institutionauthorUYSAL, HARUN
dc.contributor.institutionauthorÇALIM, MUHITTIN
dc.contributor.institutionauthorSÜMBÜL, BİLGE
dc.contributor.institutionauthorYURTSEVER, İSMAİL
dc.contributor.institutionauthorKARAASLAN, KAZıM
dc.date.accessioned2021-07-27T20:59:08Z
dc.date.available2021-07-27T20:59:08Z
dc.date.issued2021-07-01T00:00:00Z
dc.description.abstractObjective:Two critical processes in the coronavirus disease 2019 (COVID-19) pandemic involve assessing patients- intensive care needs and predicting disease progression during patients- intensive care unit (ICU) stay. We aimed to evaluate oxidative stress marker status at ICU admission and ICU discharge status in patients with COVID-19.Methods:We included patients in a tertiary referral center ICU during June-December 2020. Scores of Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA), and clinical severity, radiologic scores, and healthy discharge status were noted. We collected peripheral blood samples at ICU admission to evaluate total antioxidants, total oxidants, catalase, and myeloperoxidase levels.Results:Thirty-one (24 male, 7 female) patients were included. At ICU admission, patients- mean APACHE II score at ICU admission was 17.61 ± 8.9; the mean SOFA score was 6.29 ± 3.16. There was no significant relationship between clinical severity and oxidative stress (OS) markers nor between radiological imaging and COVID-19 data classification and OS levels. Differences in OS levels between patients with healthy and exitus discharge status were not significant.Conclusions:We found no significant relationship between oxidative stress marker status in patients with COVID-19 at ICU admission and patients- ICU discharge status.
dc.identifier.citationcoronavirus disease 2019
dc.identifier.doi10.1177/03000605211027733
dc.identifier.pubmed34310245
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29092
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCatalase
dc.subjectmyeloperoxidase deficiency
dc.subjectcritical care
dc.subjectoxidative stress
dc.subjectdischarge status
dc.titleUsefulness of oxidative stress marker evaluation at admission to the intensive care unit in patients with COVID-19
dc.typeArticle
dspace.entity.typePublication
local.avesis.id366abe8b-8005-4c94-8290-c0311569259b
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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