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Anti-inflammatory and antioxidative properties of honey bee venom on Freund’xxs Complete Adjuvant-induced arthritis model in rats

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dc.contributor.authorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.authorGÜLER, ERAY METİN
dc.contributor.authorKALELİ, SÜLEYMAN
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorGÜLER, ERAY METİN
dc.date.accessioned2019-10-05T23:14:45Z
dc.date.available2019-10-05T23:14:45Z
dc.date.issued2019-04-01
dc.description.abstractThe aim of this study was to assess anti-inflammatory, anti-oxidant, anti-genotoxic and immunomodulatory effects of honey bee venom (HBV) on adjuvant-induced arthritis in rats. Thirty-five rats were equally divided into a negative control (NC), a positive control (PC) and low, moderate and high doses (2, 4 and 20 mg/kg, respectively) of HBV treatment groups. Freund-s Complete Adjuvant (FCA) was given to the rats to form arthritis. The treatment groups were treated with HBV for 3 consecutive weeks. After the treatment, plasma IL-1 beta, IL-6, TNF-alpha, IFN-gamma and TGF-beta 1, total oxidant status (TOS), total antioxidant status (TAS) and myeloperoxidase (MPO) activities and mononuclear leukocyte (MNL) DNA damage levels were measured. Oxidative stress index (OSI) was calculated. IL-beta, IL-6, TNF-alpha, TGF-beta 1, IFN-gamma, TOS, OSI, DNA damage levels and MPO activities were significantly higher and TAS levels were lower in the PC group than the NC. After low-doses of HBV treatment IL-1 beta, IL-6, TNF-alpha, TGF-beta 1, TOS, OSI, MPO and MNL-DNA damage levels significantly decreased according to the PC, while IFN-gamma and TAS levels increased. The differences in moderate and high-dose HBV treatment groups were not as significant as low HBV doses. Low-doses of HBV has been shown to treat RA with anti-inflammatory and antioxidant effects, by preventing DNA damage. However, these effects have not been observed as strong at higher doses of HBV. In summary, HBV may be an effective option to ameliorate RA, but the optimization of the therapeutic dose has a crucial role.
dc.identifier10.14744/nci.2017.55798
dc.identifier.citationKOÇYİĞİT A., GÜLER E. M. , KALELİ S., -Anti-inflammatory and antioxidative properties of honey bee venom on Freund’xxs Complete Adjuvant-induced arthritis model in rats-, Toxicon, cilt.161, ss.4-11, 2019
dc.identifier.pubmed30825463
dc.identifier.urihttps://hdl.handle.net/20.500.12645/9798
dc.language.isoen
dc.titleAnti-inflammatory and antioxidative properties of honey bee venom on Freund’xxs Complete Adjuvant-induced arthritis model in rats
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameNorthern clinics of Istanbul
local.avesis.idf40104ab-f84d-4c8e-b74a-8e6199da676e
local.avesis.response9672
relation.isAuthorOfPublication75babbd2-f46b-4121-aa00-54d883a6f907
relation.isAuthorOfPublication68927a51-77a5-4d08-8370-23b470160061
relation.isAuthorOfPublication.latestForDiscovery68927a51-77a5-4d08-8370-23b470160061
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