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Can low-dose radiotherapy volumes be one of the contributing factors to early relapses in lung cancer patients?

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dc.contributor.authorKiziltan, Huriye Senay
dc.contributor.authorMAYADAĞLI, Alpaslan
dc.contributor.authorTEKÇE, ERTUĞRUL
dc.contributor.authorERİŞ, ALİ HİKMET
dc.contributor.authorKablan, Ozgur
dc.contributor.authorAltinok Sut, Pelin
dc.contributor.institutionauthorKIZILTAN, HURİYE ŞENAY
dc.contributor.institutionauthorMAYADAĞLI, ALPASLAN
dc.contributor.institutionauthorTEKÇE, ERTUĞRUL
dc.contributor.institutionauthorERİŞ, ALİ HİKMET
dc.contributor.institutionauthorKABLAN, ÖZGÜR
dc.contributor.institutionauthorALTINOK SÜT, PELİN
dc.date.accessioned2022-01-21T20:59:22Z
dc.date.available2022-01-21T20:59:22Z
dc.date.issued2018-03-01T00:00:00Z
dc.description.abstract© 2018 The Authors. Precision Radiation Oncology published by John Wiley & Sons Australia, Ltd on behalf of Shandong Cancer Hospital & Institute.Objective: Several studies have shown that low-dose radiotherapy (RT) might increase tumor invasion and metastases. Whereas multiple RT fields that increase low-dose RT areas are often used to prevent damage to organs at risk. We carried out a clinical trial with the concern that low-dose RT sites could increase invasions or metastases when multiple sites were used. Methods: A clinical retrospective study was carried out on 50 lung cancer patients with stage II–IIIB cancer, who underwent RT and/or chemotherapy, had Eastern Cooperative Oncology Group performances 1–3, were aged 45–87 years, and without metastases. RT was carried out for 5 days with 180–200 cGy fractions per day with a total dose of 54–66 Gy. The radiation dose volume areas V5, V10, V20, V40, V50, and V60 of lung were calculated and analyzed by Mann–Whitney U-test and L par test on disease-free and overall survival statistically. Results: It was determined that V5, V10, and V20, which constitute the low RT dose areas of the lung, positively affected the recurrence-free and overall survival minimally according to r correlation values. Conclusion: Low-dose RT volumes were positively affected minimally by recurrence-free survival and overall survival in the present study. The effects of low-dose radiation must be evaluated more clearly in studies.
dc.identifier.citationKiziltan H. S. , MAYADAĞLI A., TEKÇE E., ERİŞ A. H. , Kablan O., Altinok Sut P., -Can low-dose radiotherapy volumes be one of the contributing factors to early relapses in lung cancer patients?-, Precision Radiation Oncology, cilt.2, sa.1, ss.11-14, 2018
dc.identifier.doi10.1002/pro6.40
dc.identifier.scopus85106545499
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30249
dc.titleCan low-dose radiotherapy volumes be one of the contributing factors to early relapses in lung cancer patients?
dc.typeArticle
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