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Chemopreventive efficacy of stampidine in a murine breast cancer model

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dc.contributor.authorSahin, Kazim
dc.contributor.authorOrhan, Cemal
dc.contributor.authorOzercan, Ibrahim Hanifi
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorELİBOL, BİRSEN
dc.contributor.authorŞAHİN, TAHA KORAY
dc.contributor.authorKilic, Ulkan
dc.contributor.authorQazi, Sanjive
dc.contributor.authorUckun, Fatih Mehmet
dc.contributor.institutionauthorELİBOL, BİRSEN
dc.date.accessioned2020-03-26T20:59:09Z
dc.date.available2020-03-26T20:59:09Z
dc.date.issued2020-02-07T00:00:00Z
dc.description.abstractBackground: The purpose of the present study was to examine the chemopreventive effect of stampidine, an aryl phosphate derivative of stavudine, in side by side comparison with the standard anti-breast cancer drug paclitaxel in the well-established 7,12-dimethylbenz(a)anthracene (DMBA)-induced murine breast cancer model. Methods: Groups of 20 female mice were challenged with the DMBA. DMBA-challenged mice were assigned to various chemoprevention treatments, including stampidine, paclitaxel, and stampidine plus paclitaxel according to the same treatment schedules for 25 weeks. Results: Stampidine resulted in substantially reduced numbers of tumors, tumor weight as well as tumor size in DMBA-treated mice. Stampidine was as effective as paclitaxel in the model and their combination exhibited greater chemopreventive activity, as measured by reduced tumor incidence and improved tumor-free survival as well as overall survival of DMBA-treated mice. The length of time for the initial tumor to appear in DMBA-challenged mice treated with stampidine was longer than that of mice treated DMBA-challenged control mice. Tumors from mice treated with stampidine or stampidine plus paclitaxel displayed unique changes of a signature protein cassette comprised BRCA1, p21, Bax, and Bcl-2. Conclusion: Stampidine has potent chemopreventive activity and is as effective as the standard chemotherapy drug paclitaxel in the chemical carcinogenesis.
dc.identifier.citationSahin K., Orhan C., Ozercan I. H. , Tuzcu M., ELİBOL B., ŞAHİN T. K. , Kilic U., Qazi S., Uckun F. M. , -Chemopreventive efficacy of stampidine in a murine breast cancer model-, EXPERT OPINION ON THERAPEUTIC TARGETS, cilt.24, ss.155-162, 2020
dc.identifier.doi10.1080/14728222.2020.1724961
dc.identifier.pubmed32005098
dc.identifier.scopus85079056554
dc.identifier.urihttps://hdl.handle.net/20.500.12645/16116
dc.identifier.wosWOS:000512862400001
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectstampidine
dc.subjectcancer
dc.titleChemopreventive efficacy of stampidine in a murine breast cancer model
dc.typeArticle
dspace.entity.typePublication
local.avesis.id1315f9bf-ca47-4539-ad10-6d36d0ee34a7
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication1b1887fb-6b32-44b1-9d9f-416616dc6734
relation.isAuthorOfPublication.latestForDiscovery1b1887fb-6b32-44b1-9d9f-416616dc6734
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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